Downstream Processing White Papers and Case Studies
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Cultivation Of CHO Suspension Cells And SEAP Expression
This application note describes the cultivation of CHO suspension cells in the wave-mixed Thermo Scientific HyPerforma Rocker Bioreactor with a maximum working volume of 5 L.
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Sani-Tech® Ultra White Paper
6/29/2012
For several years, pharmaceutical manufacturing professionals have increasingly stated concerns about material leachables and extractables and their impact on the products they produce. Fluid transfer systems that include flexible tubing have been at the forefront of this discussion.
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Efficiencies Of Natural Convection In Passive Pallet Shippers
Bulk transportation of temperature sensitive pharmaceuticals and biologics has become a common practice due to complex global supply chains. By Iftekhar Ahmed, Ben VanderPlas, and Stu Krupnick
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HydroFlex™ Offers A Helping Hand For Automated Bead Washing
6/1/2012
The use of magnetic beads as the solid phase for ELISAs offers several advantages over traditional direct coupling techniques, including shorter incubation times and improved sensitivity.
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Optimizing A Growth Media Filtration System For Mycoplasma Control
Case study on helping a supplier to the biopharmaceutical industry optimize the filtration train they used to sterilize growth media into bioprocess containers while also maintaining Mycoplasma control.
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Automated Bioluminescent ADCC Reporter Bioassay Using Bioengineered Jurkat Cells
2/10/2013
Pharmaceutical companies are increasingly exploring new biologic and biosimilar products, and thus increasing monoclonal antibody (mAb) immunotherapeutic research. By Tracy Worzella, Promega Corporation and Brad Larson, Applications Department, BioTek Instruments, Inc.
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Comparing Glass And Single-Use Bioreactors For Growth And Production Of Secreted Proteins
4/15/2016
The packed-bed basket technology, developed by New Brunswick Scientific (acquired by Eppendorf Inc. in 2007), provides a shear free environment for production of animal cells. At present, little information is available on the utility of the New Brunswick CelliGen® BLU singleuse bioreactor system for the production of secreted proteins, especially in perfusion mode of operation.
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SciLog - Creating Advanced Biotech Equipment With Mettler Toledo
3/26/2012
For nearly two decades, SciLog, Inc. has been dedicated to creating revolutionary single-use purification systems and disposable sensor technologies.
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A Disposable Valve For Process Chromatography
8/15/2012
This case study discusses the need for a fully automated, disposable chromatography system which was PLC controlled and designed for use in a cGMP environment. The required applications for the chromatography system included contamination removal, and concentration and purification of biologically derived proteins used in the production of research and clinical materials.
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Quality By Design In Biomanufacturing
12/22/2011
QbD is increasingly required in our industry, but there are still gaps in understanding how QbD applies to the biomanufacturing process.