Downstream Processing White Papers and Case Studies
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Chromatography Column Protection With 3M Purification LifeASSURE™ PLA Series Membrane Filters
9/14/2011
Protective, or guard, filters are often used in chromatography column purification steps to protect the column media from contaminants in the various fluids that come in contact with the column.
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Case Study: NANOSAFE TESTED™ Summary
8/3/2011
NanoSafe, Inc. developed a testing program to independently evaluate the generation and containment of a controlled nanoaerosol inside a Labconco XPert® Nano™ System.
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Selecting The Optimal Resins For Endotoxin Depletion In Process Purification
8/3/2016
A guide to effectively remove endotoxins with versatile process resins.
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Effect Of Sterilization On Mechanical Properties Of Silicone Rubbers
6/18/2013
Silicone rubber is widely used in the pharmaceutical industry where sterilizability is an essential requirement for all fluid transfer equipment. Pharmaceutical products must be sterilized frequently and repeatedly by high level energy and/or chemical vapor in order to eliminate bacterial surface contamination.
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Strategies For Gamma Sterilization Of Pharmaceuticals
A crucial step in pharmaceutical production is sterilization. There are many sterilization methods to choose from, such as steam, sterile filtration, ethylene oxide gas (EtO), electron beam (E-beam), and gamma radiation. Each technique has aspects that make it suitable or unsuitable for the sterilization of a particular product. By Ruth Garcia, Betty Howard, Rose LaRue, Glenn Parton, and John Walker, Steris Isomedix Services
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Rapid Separation Of Basic Drug Compounds Under Alkaline pH Conditions On pH-Stable, Short .C18 Column
3/14/2013
Mobile phase pH is a powerful tool in methods development, particularly for separation of neutral forms of amines or other organic bases under alkaline conditions. By Derek Jensen and Mark Carrier, Hamilton Company
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CD69 Expression On Activated Lymphocytes Is Stable In Streck’s Cyto-Chex® BCT
7/16/2012
The purpose of this study was to determine if the activation marker, CD69, is preserved and stable in whole blood samples collected in Cyto-Chex® BCT. Previous studies have demonstrated CD marker stability of whole blood samples collected in Cyto-Chex BCT for up to 7 days when stored at room temperature (18-22°C). By Jodi Alt, Ph.D
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Optimized Sterile Filtration of Pharmaceutical Solutions
11/12/2015
The cost of filtration and separation stages within the production of pharmaceuticals has been increasing along with the increased complexity of final drug products.
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Met One Sensors Resistant To Vaporous Hydrogen Peroxide (VHP)
1/11/2012
Pharmaceutical manufacturers often require an aseptic production environment to minimize the presence of microbes and their potential contamination of the manufactured product.
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The maXis Impact™ Mass Spectrometer Identifies >1600 Proteins In A Single LC-MS/MS Experiment
11/13/2011
The analysis of complex proteomic samples is one of the most demanding tasks in proteomics studies. The sample complexity requires the utmost speed, dynamic range and sensitivity from an analytical system to be used effectively.