Downstream Processing White Papers and Case Studies
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Optimizing A Growth Media Filtration System For Mycoplasma Control
Case study on helping a supplier to the biopharmaceutical industry optimize the filtration train they used to sterilize growth media into bioprocess containers while also maintaining Mycoplasma control.
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Particle Testing in Cleanroom High-Pressure Gas Lines for ISO 14644
This paper provides guidelines for the testing of high pressure gases used in cleanrooms according to the cleanliness limits derived from the ISO 14644-1 cleanroom classification standard, the FDA cGMP guidelines and the EU GMP Guidelines. Specifically, this applications paper relates to satisfying the air particle concentration limits of Class 100 (ISO 5) where product is exposed to the air environment.
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A Disposable Valve For Process Chromatography
8/15/2012
This case study discusses the need for a fully automated, disposable chromatography system which was PLC controlled and designed for use in a cGMP environment. The required applications for the chromatography system included contamination removal, and concentration and purification of biologically derived proteins used in the production of research and clinical materials.
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Fast Quantification Of Saliva Samples In Microplates
12/7/2012
A successful evaluation study of saliva samples in microplates using Tecan’s Infinite F50 microplate reader in combination with Tecan’s Magellan™ data analysis software, using the Saliva Quantification Kit from Greiner Bio-One for the fast detection of saliva samples.
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Improving Aggregate Removal From mAb Feed Using Cation Exchange Chromatography
Researchers in the field of chromatography have required ever more sophisticated and selective methods for removing aggregates from the monomer.
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Single-Use Connections Advance Aseptic Processing
John Boehm discusses how single-use connections advance aseptic processing and create increased process flexibility and reliability while reducing costs.
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Biomanufacturing Complexity
12/22/2011
This white paper addresses one of the most serious challenges facing biomanufacturing professionals today - how to understand and then deal with the extreme complexity associated with biotechnology manufacturing.
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Global Biochemical Profiling For Bioprocess Optimization
6/12/2013
It is widely understood that the production phase of bioprocessing can have a significant impact on the overall profitability of the biopharmaceutical.
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One Bioreactor System For The Bioproduction Of 2 High-Demand Chemicals
7/28/2016
A large variety of chemicals can be efficiently produced by microbial fermentation. They are used in a multitude of applications; for example, as biofuels, building blocks for polymers, food supplements, and ingredients for cosmetics. To be profitable, fermentation processes have to deliver the desired end product at a high yield and a high titer.
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Cultivation Of CHO Suspension Cells And SEAP Expression
This application note describes the cultivation of CHO suspension cells in the wave-mixed Thermo Scientific HyPerforma Rocker Bioreactor with a maximum working volume of 5 L.