Harvest & Collection
PRODUCTS
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![GettyImages-1327977866-cell-culture-sample-laboratory]( "Development Solutions For Biologics CHO CLD Platforms")
Aragen offers choice of CLD platforms, efficient Upstream and Downstream process development
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![BE4]( "Small Batch Pharmaceutical Blister Packaging System: BE4")
Ideal for small batch sizes, many format changes, or a wide variety of packaging materials – the BE4 reliably meets all requirements. It enables a highly efficient process thanks to the two-lane operation with a very small footprint. Thanks to the 100% modular concept of the Blister Expert platform, the BE4 can be upgraded to a high-speed solution at any time.
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![GettyImages-1175279159 powder]( "Onsite Preclinical Services To Support Your Product Development: Powder Micromeritics")
Understanding the fine details of powder properties is crucial in the pharmaceutical industry, where the behavior of particulate matter can affect manufacturability and the efficacy of the final product.
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![HPLC Chromatography laboratory scientist GettyImages-1309780330]( "Analytical & Quality Control")
Learn how robust in-house analytical services and protein characterization are crucial for successful development and manufacturing programs.
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![Office-meeting-GettyImages-1353983621]( "Pre-Approval Inspection (PAI) Readiness")
Our team of experts are equipped to guide you through every step of any Inspection, especially Pre-Approval Inspections, due to the nature of their criticality.
WHITE PAPERS AND CASE STUDIES
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![GettyImages-1356054921-glass-vials-pharmaceutical]( "Monitoring Laser Power In Laser-Based Fill & Finish Biopharmaceutical Systems")
Monitoring Laser Power In Laser-Based Fill & Finish Biopharmaceutical SystemsCustom laser power measurement ensures precise vaccine vial sealing, meeting strict biopharma compliance standards through tailored detectors, firmware, and calibration for critical fill-finish applications.
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![Doctor Using Digital Tablet GettyImages-1530254515]( "How Vanguard Clinical Harnesses CDMS/EDC For Faster Results")
How Vanguard Clinical Harnesses CDMS/EDC For Faster ResultsUncover how this CRO was able to stay agile by choosing a CDMS/EDC partner that prioritized sponsor needs and streamlined operations to achieve top-tier results swiftly.
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![Intestinal tract with digestive health-GettyImages-1985026058]( "Predicting Food Effects In Oral Drug Delivery Using PBPK Modeling")
Predicting Food Effects In Oral Drug Delivery Using PBPK ModelingLearn how integrated PBPK and molecular dynamics modeling predicted an ~11% fed-state Cmax increase for fenofibrate, giving formulation teams earlier, mechanistic insight into food-dependent absorption.
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![GettyImages-1298781737 aseptic filling]( "Vaccine Fill Line Operations")
Vaccine Fill Line OperationsLearn how adopting a harmonized, risk-based validation strategy across global sites can reduce operational readiness timelines and drive improvements in equipment effectiveness and regulatory compliance
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![WOL_south-dearborn_385x250]( "Resolving Odor Complaints With Targeted Solutions Restore Community Confidence")
Resolving Odor Complaints With Targeted Solutions Restore Community ConfidenceThe South Dearborn Regional Sewer District in Lawrenceburg, Indiana, provides regional wastewater treatment services for three cities and an international distillery. The 6 mgd treatment plant is located in an area of high population growth and is surrounded by many retail operations and other commercial developments. In addition, a heavily traveled state highway runs by the treatment plant.
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![Superior Fresh CS]( "How Superior Fresh Is Pioneering Sustainable Aquaculture With Pinnacle Ozone Solutions")
How Superior Fresh Is Pioneering Sustainable Aquaculture With Pinnacle Ozone SolutionsSee how Superior Fresh uses advanced ozone technology to maintain pristine aquaculture water quality, supporting sustainable Atlantic salmon production and organic farming in a pioneering integrated system.
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![GettyImages-1938951579-automation-filling-bottles-modern-robot-manufacturing]( "Digital Transformation Optimizes Production, Quality, And Compliance")
Digital Transformation Optimizes Production, Quality, And ComplianceDiscover how advanced automation solutions at Fermion's new facility were implemented to enhance production, quality, and compliance in pharmaceutical manufacturing while meeting industry standards.
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![GettyImages-2036497698 clinical lab]( "Robust, Scalable Strategy For Monodisperse Nanosuspensions Of Poorly Soluble Drugs")
Robust, Scalable Strategy For Monodisperse Nanosuspensions Of Poorly Soluble DrugsBy tailoring the formulation strategy, selecting the appropriate excipients, and fine-tuning process conditions, see how our team was able to improve bioavailability and in vivo exposure.
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![GettyImages-820772090 eyes]( "Global Start-Up For Multinational Geographic Atrophy Trial")
Global Start-Up For Multinational Geographic Atrophy TrialThis partnership allowed a leading biopharmaceutical company to navigate the complexities of a Phase IIb study investigating a novel pegylated RNA adapter for geographic atrophy secondary to dry AMD.
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![GettyImages-1375233514 brewery]( "Water Disinfection At Feldschlöesschen Brewery In Switzerland")
Water Disinfection At Feldschlöesschen Brewery In SwitzerlandDespite meeting European drinking water standards, contamination levels at a brewery reached as high as 800 CFU/ml, prompting the brewery to seek a reliable disinfection solution to protect the integrity of its production processes.
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![Menlo - switch array]( "Unlocking Endurance With MEMS Technology: Extending Relay Lifespan By 1000x")
Unlocking Endurance With MEMS Technology: Extending Relay Lifespan By 1000xExplore how innovative Ideal Switch technology is setting new benchmarks for reliability and efficiency in semiconductor testing.
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![GettyImages-1439780284 (1) milk bottling]( "Pasteurized Equivalent Water For AgriMark-Cabot Dairy In Vermont")
Pasteurized Equivalent Water For AgriMark-Cabot Dairy In VermontDiscover how AgriMark-Cabot Dairy transformed wastewater into a valuable resource using UV technology, achieving significant energy and water savings while maintaining stringent food safety standards.
NEWS
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Trident IoT Unveils Revolutionary Software Development Kits For Z-Wave/ZWLR And Zigbee RF SoCs4/2/2025
Trident IoT is proud to announce the release of its highly anticipated Software Development Kits (SDKs) for its latest line of Z-Wave/ZWLR and Zigbee RF System-on-Chips (SoCs).
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NEOVAC Presents Innovative Vacuum Coating Technology For High-Strength Steels With No Thermal Stress8/27/2025
NEOVAC, a joint venture between SMS group GmbH and SITIZN Group Holding AG, based in Karlstein, Germany, is proud to present a brand new technology for coating steel strip, which was specially developed for high-strength and ultra-high-strength steels.
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Researchers Develop New Design And Fabrication Method To Make Lightsails For Interstellar Travel3/27/2025
Since its launch in 1977, NASA’s Voyager 1 spacecraft has traveled over 15 billion miles into deep space.
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A Supersolid Made Using Photons3/10/2025
Manuele Landini from the University of Innsbruck was part of an international team led by researchers at CNR Nanotec in Lecce, Italy, that has demonstrated the emergence of a supersolid phase of matter in a photonic crystal polariton condensate.
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SPML Infra Wins ₹385 Crore (USD 45 Million) Order For Water Infrastructure Project In Rajasthan Under The Jal Jeevan Mission7/11/2025
SPML Infra Limited, SPML Infra Limited, India’s leading water infrastructure company, has been awarded a prestigious ₹385 crore (USD 45 Million) project for the Water Production & Supply System for Kekri-Sarwar Sector Package-III in Ajmer, Rajasthan.
ABOUT
Harvest and Collection
Harvest and collection is the process used to retrieve biological agents and vaccines present in cell cultures or to harvest and collect stem cells from blood or bone marrow. Many bioresearch companies have sophisticated systems for harvesting and collecting cells. These systems make counting cells easier and they also protect against contamination.
Cells are harvested once the cells reach a density level in the cell culture medium that precludes further growth. The best time to harvest cells is when they are in a confluent state (at least 50% of the culture dish is covered and before 100% of the dish is covered).
Cells can be harvested using on of three methods: Mechanical, using Proteolytic enzymes, or using EDTA. Mechanical harvesting uses a rubber spatula to remove the cells from the growth surface or culture. This method is quick but can cause many cells to die because it is highly disruptive. This method is favored when harvesting lots of different samples of cells to prepare extracts.
In this case, viability of the cells doesn’t matter. Three enzymes; Trypsin, Collagenase, and Pronase can be used in combination with EDTA. The combination of these enzymes with the EDTA makes cells detach from the growth medium.
This method is easy but also has a downside. It can damage the cell surface by eating up exposed cell surface proteins. EDTA can be used alone to detach cells from their medium and it is gentler than using trypsin.
Normally, collected cells are placed in a new suspension, or growth medium to continue growing new cultures. This is referred to as passaging or splitting the cells.