Harvest & Collection
PRODUCTS
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Every capsule and tablet begins with an idea. It takes a professional and innovative manufacturing partner to turn that idea into a reality. Enter Natoli, a name synonymous with excellence in pharmaceutical equipment and services. From the early stages of formulation to the grand scale of full-blown production, Natoli offers a seamless journey through every step of the process. Whether you’re unsure of how to start or how to finish, Natoli can guide the way.
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As the industry’s most advanced digital construction management system, Trimble e-Builder enables efficiencies across the entire design-build lifecycle, with a smooth transition to the operation phase. Reduce risk, enhance collaboration and improve outcomes using the industry-leading digital project delivery software for owners.
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Planning to launch a patient-centric decentralized clinical trial? Give your clinical trial patients an app that makes it easy to participate—from anywhere at any time.
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PHCbi brand's 10.4 cu.ft. (294 L) humidified plant growth chamber is designed to helps ensure highly accurate, reproducible chamber conditions. It allows for precise control of temperature, humidity, and lighting - making it ideal for drosophila breeding, diurnal growth studies, plant cell culturing and more. Robust cabinet construction with corrosion-resistant stainless-steel surfaces simplify cleaning and eliminate rust due to high humidity. It uses SNAP compliant, low flammability HFO refrigerants to assure low environmental impact.
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Free your safety and clinical teams to focus on what matters most.
WHITE PAPERS AND CASE STUDIES
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Global Start-Up For Multinational Geographic Atrophy Trial
This partnership allowed a leading biopharmaceutical company to navigate the complexities of a Phase IIb study investigating a novel pegylated RNA adapter for geographic atrophy secondary to dry AMD.
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RTSM And Clinical Drug Dispensation
A pharma company used Signant Health's RTSM solution in a Phase 2 schizophrenia trial to ensure drug availability, maintain study balance, prevent duplicate allocations, and manage returns and destruction of unused drugs.
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Scalable Production Of High-Purity Nanobodies Using Yeast Expression System
Leverage scalable K. pastoris expression systems to produce high-quality nanobodies for cutting-edge therapeutic, diagnostic, and research applications.
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Minnetonka, MN Pilots Acoustic Pipe Assessment Prior To Road Resurfacing
A Minnesota suburb used non-invasive acoustic technology to assess an aging water main before a 20-year road construction moratorium. This critical data allowed them to confidently prioritize pipe renewals and better manage their infrastructure budget.
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Accelerating A Complex Molecule From CLD To cGMP In 12 Months
Learn how to mitigate technical risk, implement parallel process development, and design custom purification strategies for highly sensitive novel modalities to accelerate to cGMP material.
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How Optina Diagnostics Used EDC In Earlier Disease Detection
Understand how Optina Diagnostics streamlined operations and achieved significant milestones by leveraging Castor's tools in its effort to revolutionize the diagnostic process for Alzheimer’s.
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Achieving A 2.67x Reduction In Study Build Time For An Innovative Neuromodulation Study
This study explores the potential of Focused Ultrasound Neuromodulation in deepening meditative states, and the platform that helps enhance the overall experience for researchers and participants alike.
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Disinfection For Drinking Water Plant In Chennai, India
The Chennai Metropolitan Water Supply and Sewerage Board (CMWSSB) encountered significant challenges in treating high algae loads at its drinking water plant, which processes 1.5 million liters of water daily. The primary issue arose from the organic load in lake water, which, when treated with conventional chlorine disinfectants, resulted in harmful disinfection byproducts (DBPs).
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Robust, Scalable Strategy For Monodisperse Nanosuspensions Of Poorly Soluble Drugs
By tailoring the formulation strategy, selecting the appropriate excipients, and fine-tuning process conditions, see how our team was able to improve bioavailability and in vivo exposure.
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Leveraging Single-Use Solutions To Solve Working Cell Bank Challenges
Discover how custom manifolds enhance allogeneic therapy development from formulation to commercialization by improving process control, scalability, and efficiency.
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Drilling Down On Diversity And Feasibility
A mid-sized contract research organization (CRO) sought help with writing clinical trial diversity action plans and assessing feasibility for therapeutic areas outside its usual scope.
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Explore A High-Performing Basal Medium And Feed Pairing
A customer sought to replace a chemically defined CHO medium with a more efficient medium and feed pairing strategy in bioreactors.
NEWS
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Motivosity Launches Lifestyle Spending Accounts To Help Companies Offer Flexible, Hassle-Free Employee Perks5/27/2025
Motivosity, the leading people-first employee recognition and rewards platform built for today’s workforce, is proud to announce the launch of its new Lifestyle Spending Accounts (LSAs) program.
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NX Filtration And Eau d'Azur Partner For Advanced Micropollutant Treatment In Nice8/25/2025
NX Filtration, a global leader in advanced hollow fiber membrane technology, is proud to announce its collaboration with Eau d’Azur, the public company responsible for drinking water and wastewater services for the Nice Côte d'Azur Metropole.
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Shell Expands Gulf Of America Leadership Position With Dover Development4/8/2025
Shell Offshore Inc. (Shell), a subsidiary of Shell plc, today announced the start of production at Dover, the second subsea tieback connecting new wells to the existing infrastructure of the Shell-operated Appomattox production hub in the Gulf of America.
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PulpFixin Announces Strategic Distribution Partnership With Wildcat Laboratory Solutions To Expand Sustainable Lab Products Across The UK And EU4/14/2025
PulpFixin, an innovator of sustainable laboratory products, announced today a new distribution partnership with Wildcat Laboratory Solutions a leading provider of lab equipment and solutions across the United Kingdom and European Union.
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Evonik Partners With ST Pharm To Increase Its Offerings For RNA And Nucleic Acid Delivery1/8/2025
Evonik is partnering with ST Pharm, a company that manufactures active ingredients for gene therapy, to expand its RNA and nucleic acid therapeutic services.
ABOUT
Harvest and Collection
Harvest and collection is the process used to retrieve biological agents and vaccines present in cell cultures or to harvest and collect stem cells from blood or bone marrow. Many bioresearch companies have sophisticated systems for harvesting and collecting cells. These systems make counting cells easier and they also protect against contamination.
Cells are harvested once the cells reach a density level in the cell culture medium that precludes further growth. The best time to harvest cells is when they are in a confluent state (at least 50% of the culture dish is covered and before 100% of the dish is covered).
Cells can be harvested using on of three methods: Mechanical, using Proteolytic enzymes, or using EDTA. Mechanical harvesting uses a rubber spatula to remove the cells from the growth surface or culture. This method is quick but can cause many cells to die because it is highly disruptive. This method is favored when harvesting lots of different samples of cells to prepare extracts.
In this case, viability of the cells doesn’t matter. Three enzymes; Trypsin, Collagenase, and Pronase can be used in combination with EDTA. The combination of these enzymes with the EDTA makes cells detach from the growth medium.
This method is easy but also has a downside. It can damage the cell surface by eating up exposed cell surface proteins. EDTA can be used alone to detach cells from their medium and it is gentler than using trypsin.
Normally, collected cells are placed in a new suspension, or growth medium to continue growing new cultures. This is referred to as passaging or splitting the cells.