Harvest & Collection
PRODUCTS
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![Compounding Aseptic Containment Isolator]( "Aseptic Containment Isolator For Compounding")
Germfree’s Compounding Aseptic Containment Isolators use HEPA filters to provide the highest level of operator and product protection.
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![info360-plant]( "Info36o Plant")
Autodesk® Info360® Plant is a cloud-based operational analytics solution within the Info360 platform designed specifically for water and wastewater treatment plants to improve real-time data analysis and enable workflows associated with performance, compliance, and improvement planning.
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![GettyImages-669121480-pill-tablet-capsule-OSD-oral-solid]( "Compaction Simulation / Emulation")
Building on the capabilities of the NP-RD10A benchtop tablet press (discussed in our previous article on USP <1062>), our services are further enhanced by the integration of the Presster™ compaction emulator. This state-of-the-art tool is designed to replicate the compaction dynamics of production tablet presses in a laboratory setting. It allows for tangible fine-tuning of the compression cycle, providing an accurate depiction of how a tablting formulation will behave under commercial manufacturing conditions. Using the Presster, Natoli Scientific can simulate full-scale production, permitting us to forecast problems before they escalate to costly production delays. Our experts can optimize the tablet design for our clients, ensuring a smooth transition from laboratory to production while adhering to the rigorous standards set by the industry including the current USP <1062> chapter.
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![GettyImages-1425605790 Life Sciences Training. Scientists Using A Computer In A Lab]( "Qualified Person (QP) Services")
Providing around-the-clock support, enabled by at least two QPs per assignment, delivering full continuity, and reduced risk.
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![Scientist-with-tablet-GettyImages-950594528]( "Unlocking Pharmaceutical Success: From Idea To Reality")
In the pharmaceutical industry, every capsule and tablet begins with a concept. Transforming that idea into a tangible product requires an expert manufacturing partner. Natoli stands out as a leader in pharmaceutical equipment and services, providing a comprehensive journey from formulation to full-scale production.
WHITE PAPERS AND CASE STUDIES
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![Risk Management-GettyImages-665231256]( "Flexible Integrations To Reduce Risks And Increase Efficiencies")
Flexible Integrations To Reduce Risks And Increase EfficienciesLearn how a trial team kept the blind of central lab samples and patient treatment across a Phase III and extension trial, whilst optimizing the supply chain.
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![pasadena-TX]( "Next-Gen Submersible Solids Handling Pump Helps Protect Pasadena, Texas")
Next-Gen Submersible Solids Handling Pump Helps Protect Pasadena, TexasA submersible solids handling pump featuring a semi-open impeller and self-cleaning cutter plate solved a severe clogging issue. Operating without a single clog for over six months, the technology delivered "100% uptime" and freed up staff for other vital maintenance.
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![eye drops-GettyImages-1406386094]( "Rapid Results In A High-Stakes Dry Eye Disease Trial")
Rapid Results In A High-Stakes Dry Eye Disease TrialThis time-sensitive Phase 3 trial in dry eye disease required precision project management leveraging strong site relationships, ophthalmology-specific expertise, and data-driven site selection.
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![GettyImages-1327112218 Scientist using a laptop in a laboratory]( "Electronic Batch Reporting")
Electronic Batch ReportingLearn how a CDMO automatically created a comprehensive batch report model to drive their reporting and speed root cause identification of quality failures with an Industrial DataOps software solution.
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![GettyImages-1130068128 laser beam]( "Innovative Measurement Technology Enables Next Level Industrial AM")
Innovative Measurement Technology Enables Next Level Industrial AMReichenbacher Hamuel uses Ophir’s BeamPeek system to enhance laser quality in additive manufacturing, ensuring optimal beam performance and reliability across development, maintenance, and troubleshooting stages.
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![GettyImages-1039397968 trial timing]( "Partnering For Precision In An IPF Study: Securing Timely Deliverables And Key Endpoints")
Partnering For Precision In An IPF Study: Securing Timely Deliverables And Key EndpointsA pharmaceutical company enlisted Worldwide Clinical Trials to help achieve on-time results for their Phase IIa IPF clinical trial, enabling them to manage vendors and meet challenging deadlines.
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![GettyImages-1152357186 data, AI]( "Data Key In Addressing Patient Recruitment Challenges")
Data Key In Addressing Patient Recruitment ChallengesExplore how a Phase II trial for extensive-stage and previously treated small cell lung cancer overcame recruitment challenges with a data-driven solution designed to surface protocol-matched patients.
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![GettyImages-1296415689 trial diversity]( "Drilling Down On Diversity And Feasibility")
Drilling Down On Diversity And FeasibilityA mid-sized contract research organization (CRO) sought help with writing clinical trial diversity action plans and assessing feasibility for therapeutic areas outside its usual scope.
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![Developing mRNA Vaccines GettyImages-1307593959]( "Improving Pre-Clinical Study Efficiency With mRNA-LNP Technology")
Improving Pre-Clinical Study Efficiency With mRNA-LNP TechnologyUncover how Repair Biotechnologies, in collaboration with Vernal Biosciences, helped to pave the way for the next generation of breakthrough treatments for cholesterol and aging-related diseases.
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![city-of-stuart]( "Actuators On Aeration Blower Valves Improve Dissolved Oxygen And Increase Overall Process Stability")
Actuators On Aeration Blower Valves Improve Dissolved Oxygen And Increase Overall Process StabilityDiscover how installing Beck electric actuators on the aeration blower control valves has improved process stability and plant operations for a South Florida treatment plant.
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![iStock-1183376856-mice-mouse-study]( "A Translational Mouse Model For Non-Genetic Heterotopic Ossification")
A Translational Mouse Model For Non-Genetic Heterotopic OssificationReproducing the thermal lesion/tenotomy-induced mouse model can help overcome the challenge of unpredictable heterotopic ossification localization and enable the development of targeted interventions.
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![chennai-india]( "Disinfection For Drinking Water Plant In Chennai, India")
Disinfection For Drinking Water Plant In Chennai, IndiaThe Chennai Metropolitan Water Supply and Sewerage Board (CMWSSB) encountered significant challenges in treating high algae loads at its drinking water plant, which processes 1.5 million liters of water daily. The primary issue arose from the organic load in lake water, which, when treated with conventional chlorine disinfectants, resulted in harmful disinfection byproducts (DBPs).
NEWS
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Be Part of Photonics Future: CIOE 2025 Visitor Registration Live Now!4/9/2025
The 26th China International Optoelectronic Exposition (CIOE 2025) is set to take place from September 10–12, 2025, at the Shenzhen World Exhibition & Convention Center, spanning 240,000 square meters of exhibition space.
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Anritsu Supports Evaluation Of 5G NR NTN Devices For Satellite-Based Communications7/29/2025
Anritsu Corporation, a global leader in test and measurement solutions, is pleased to announce that its Radio Communication Test Station MT8000A, a measurement solution for 5G devices such as smartphones, now supports evaluation of 5G NR NTN devices for non-terrestrial networks (NTN), which enables communication via satellite.
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GD Energy Products' Y-Shaped Drilling Module Now Rated For 10,000 PSI8/18/2025
GD Energy Products (GDEP), the leading total solutions provider for the frac, drilling and well servicing pumps market, has announced its patented Y-Shaped Drilling Module is now rated for operating pressures up to 10,000 psi.
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Canada Accelerates Transition To Zero-Emissions Vehicles8/13/2025
Canada is leading the way on the infrastructure, innovation and partnerships required to transition to electric transportation.
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SJW Infrastructure Improvement Progressing At Cambrian Tank Replacement Project5/29/2025
San Jose Water (“SJW” or “the Company”), a wholly owned subsidiary of H2O America, has made meaningful progress on its Cambrian Tank Replacement project, a major investment in the long-term reliability and seismic resilience of the Company’s water system.
ABOUT
Harvest and Collection
Harvest and collection is the process used to retrieve biological agents and vaccines present in cell cultures or to harvest and collect stem cells from blood or bone marrow. Many bioresearch companies have sophisticated systems for harvesting and collecting cells. These systems make counting cells easier and they also protect against contamination.
Cells are harvested once the cells reach a density level in the cell culture medium that precludes further growth. The best time to harvest cells is when they are in a confluent state (at least 50% of the culture dish is covered and before 100% of the dish is covered).
Cells can be harvested using on of three methods: Mechanical, using Proteolytic enzymes, or using EDTA. Mechanical harvesting uses a rubber spatula to remove the cells from the growth surface or culture. This method is quick but can cause many cells to die because it is highly disruptive. This method is favored when harvesting lots of different samples of cells to prepare extracts.
In this case, viability of the cells doesn’t matter. Three enzymes; Trypsin, Collagenase, and Pronase can be used in combination with EDTA. The combination of these enzymes with the EDTA makes cells detach from the growth medium.
This method is easy but also has a downside. It can damage the cell surface by eating up exposed cell surface proteins. EDTA can be used alone to detach cells from their medium and it is gentler than using trypsin.
Normally, collected cells are placed in a new suspension, or growth medium to continue growing new cultures. This is referred to as passaging or splitting the cells.