Harvest & Collection
PRODUCTS
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Manufacture high-quality products with streamlined compliance.
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Every capsule and tablet begins with an idea. It takes a professional and innovative manufacturing partner to turn that idea into a reality. Enter Natoli, a name synonymous with excellence in pharmaceutical equipment and services. From the early stages of formulation to the grand scale of full-blown production, Natoli offers a seamless journey through every step of the process. Whether you’re unsure of how to start or how to finish, Natoli can guide the way.
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Analyzing bacteria concentrations without any pre-processing.
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Many owners and installers prefer the strength and simplicity of HDSS Pipe and Fittings. The joint is integrally restrained which gives it four advantages:
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The PE42447 is an SP4T RF switch that supports a frequency range from 10 MHz to 8 GHz. It delivers extremely low insertion loss and high linearity with high input power handling.
WHITE PAPERS AND CASE STUDIES
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Navigating Regulatory Compliance: A Success Story In The Pharma Industry
Reveal how one pharmaceutical facility overcame strict cross-contamination rules and space limits without costly building modifications to ensure operational continuity.
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How Optina Diagnostics Used EDC In Earlier Disease Detection
Understand how Optina Diagnostics streamlined operations and achieved significant milestones by leveraging Castor's tools in its effort to revolutionize the diagnostic process for Alzheimer’s.
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Achieving Excellence In Clinical Research And Quality Management
Lotus Clinical Research, founded in 2001, leverages regulatory expertise and digitalization to enhance quality, automate processes, and improve compliance in biopharmaceutical clinical trials.
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Disinfection For Drinking Water Plant In Chennai, India
The Chennai Metropolitan Water Supply and Sewerage Board (CMWSSB) encountered significant challenges in treating high algae loads at its drinking water plant, which processes 1.5 million liters of water daily. The primary issue arose from the organic load in lake water, which, when treated with conventional chlorine disinfectants, resulted in harmful disinfection byproducts (DBPs).
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Achieving Complete Destruction Of PFAS Using electraCLEAR Process
In early 2023, Lacks Enterprises Inc., a large automotive component supplier in the midwestern US, engaged Axine to address destruction of legacy PFAS compounds in wastewater from its manufacturing processes.
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Electronic Batch Reporting
Learn how a CDMO automatically created a comprehensive batch report model to drive their reporting and speed root cause identification of quality failures with an Industrial DataOps software solution.
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Vaccine Fill Line Operations
Learn how adopting a harmonized, risk-based validation strategy across global sites can reduce operational readiness timelines and drive improvements in equipment effectiveness and regulatory compliance
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Changing The Clinical Feasibility Game With AI
AI is only as good as the data it’s built upon. Our customized AI platforms are constructed on a foundation of trustworthy, carefully curated data to produce detailed, expert-driven responses.
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Life Sciences Corporation Implements eLogbooks Across 15 Sites
New regulations challenged how surgical kits were tracked and processed across 15 U.S. sites. Discover how one team balanced compliance and efficiency to keep life-saving procedures on schedule.
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Whether Half-Empty Or Half Full, Krohne Helps Back River Accurately Measure Flow
If a pipe in a wastewater treatment plant is only 50% filled, it doesn't matter whether you call a glass half full or half empty. When it comes to measuring the liquid in that pipe, either way presents a significant problem.
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AMERICAN And Partners Install Boltless Restrained Underwater Pipeline System In Ashland, Wisconsin
Beneath the waters of Chequamegon Bay on Lake Superior in Ashland, Wisconsin, about 4,500 feet of 24-inch AMERICAN Flex-Ring Ductile Iron Pipe and a submerged timber crib intake structure were installed to ensure the city’s residents have quality drinking water for the next 100 years. The Ashland Water Intake Project began May 1, 2025, and is now complete.
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Digital Transformation - The Power Of Your Data
Discover how you can circumvent numerous recirculations during the ultrafiltration process step, boost downstream bioprocess yield, and identify and resolve process inefficiencies.
NEWS
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AEON Biopharma Appoints Industry Veteran Rob Bancroft As Chief Executive Officer4/21/2025
AEON Biopharma, Inc. (“AEON” or the “Company”) (NYSE: AEON), a clinical-stage biopharmaceutical company focused on developing a botulinum toxin complex for the treatment of multiple therapeutic indications, announced today the appointment of Rob Bancroft as President and Chief Executive Officer, effective April 29, 2025. Mr. Bancroft will also join AEON’s Board of Directors.
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Aircraft Toilets Could Flush Out Spread Of Global Superbugs8/18/2025
Wastewater from aircraft toilets could provide a critical warning system for the global spread of antimicrobial resistant (AMR) superbugs, a silent pandemic that threatens to kill more people than cancer by 2050.
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Silo Pharma Expands Intellectual Property Portfolio With Patent Application For Exclusively Licensed Alzheimer's Drug4/28/2025
Silo Pharma, Inc. (Nasdaq: SILO) (“Silo” or the “Company”), a developmental stage biopharmaceutical company focused on novel therapeutics and drug delivery systems, today announced the filing of a patent application with the U.S. Patent and Trademark Office (USPTO) focused on the neurology drug SPC-14, an intranasal compound for the treatment of Alzheimer’s disease (AD) exclusively licensed to Silo Pharma from Columbia University.
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Ovarro Opens New Asia Pacific Headquarters8/27/2025
Water technology provider Ovarro has opened a new Asia Pacific headquarters and production facility in Selangor, Malaysia.
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Canada Accelerates Transition To Zero-Emissions Vehicles8/13/2025
Canada is leading the way on the infrastructure, innovation and partnerships required to transition to electric transportation.
ABOUT
Harvest and Collection
Harvest and collection is the process used to retrieve biological agents and vaccines present in cell cultures or to harvest and collect stem cells from blood or bone marrow. Many bioresearch companies have sophisticated systems for harvesting and collecting cells. These systems make counting cells easier and they also protect against contamination.
Cells are harvested once the cells reach a density level in the cell culture medium that precludes further growth. The best time to harvest cells is when they are in a confluent state (at least 50% of the culture dish is covered and before 100% of the dish is covered).
Cells can be harvested using on of three methods: Mechanical, using Proteolytic enzymes, or using EDTA. Mechanical harvesting uses a rubber spatula to remove the cells from the growth surface or culture. This method is quick but can cause many cells to die because it is highly disruptive. This method is favored when harvesting lots of different samples of cells to prepare extracts.
In this case, viability of the cells doesn’t matter. Three enzymes; Trypsin, Collagenase, and Pronase can be used in combination with EDTA. The combination of these enzymes with the EDTA makes cells detach from the growth medium.
This method is easy but also has a downside. It can damage the cell surface by eating up exposed cell surface proteins. EDTA can be used alone to detach cells from their medium and it is gentler than using trypsin.
Normally, collected cells are placed in a new suspension, or growth medium to continue growing new cultures. This is referred to as passaging or splitting the cells.