Harvest & Collection
PRODUCTS
-
Every capsule and tablet begins with an idea. It takes a professional and innovative manufacturing partner to turn that idea into a reality. Enter Natoli, a name synonymous with excellence in pharmaceutical equipment and services. From the early stages of formulation to the grand scale of full-blown production, Natoli offers a seamless journey through every step of the process. Whether you’re unsure of how to start or how to finish, Natoli can guide the way.
-
We support you in the process of optimally implementing complex Manufacturing Execution Systems. In addition to the creation of Master Batch Records (MBRs) and Electronic Batch Recording (EBR), including classic data acquisition and preparation, as well as all other processes that have immediate effects on the manufacturing process.
-
Consider the benefits of an integrated operations and project management approach across all phases and regions.
-
Our team of experts are equipped to guide you through every step of any Inspection, especially Pre-Approval Inspections, due to the nature of their criticality.
-
The MEQ6-45CSP1 is a passive MMIC equalizer CSP ideal for compensating for low pass filtering effects in RF/microwave and high speed digital systems.
WHITE PAPERS AND CASE STUDIES
-
Accelerate Your Oncology Breakthroughs
Finding the right partnership can help your oncology clinical trials overcome trial complexities through strategic planning, a deep scientific understanding, and operational excellence.
-
Meeting 100% Recruitment 7 Months Ahead Of Schedule
Uncover the detailed outcomes of this extensive Phase 3 clinical trial on a new biosimilar for non-small cell lung cancer.
-
Addressing Site Selection Challenges In DMD Gene Therapy Studies
Effective site selection is critical for the success of DMD gene therapy trials. This study details innovative methodologies employed to streamline and improve site identification.
-
Contamination In The Shadows: Risks Lurking From Environmental Issues
Discover how science-based bio-decontamination strategies effectively eliminate invisible pathogens and rapidly restore facilities to operational safety following major infrastructure disruptions.
-
eCOA: Unified Approach Streamlines Processes, Speeds Start Up And Improves Data Quality
Discover how a leading biopharmaceutical company revolutionized its clinical development with an eCOA solution that optimized its processes, cut build times, and enhanced data quality.
-
Building A Scalable Oncology Engine In A Dynamic Market
Learn how a top-10 global pharmaceutical company partnered with Medable to rapidly scale the number of oncology trials it could concurrently conduct.
-
Custom Mobile Pharmacy Cleanroom Trailer For Oncology Infusion Pharmacy Services
Gain insight into the mobile cleanroom that was created to accommodate the needs of Moffitt Cancer Center's Oncology Infusion Pharmacy Services and adhere to USP <797> and <800> standards.
-
Poultry Panic: Urgent Wastewater Fix Saves Poultry Plant From Fines
On a late Friday afternoon in June, a call came in to USP Technologies (USP): a major poultry processing plant in the southeast was in danger of violating their wastewater discharge permit.
-
How Waterloo Harnessed Qatium's Digital Platform
Read about the City of Waterloo, that needed an intuitive, low-cost tool to empower operators without requiring specialized technical expertise.
-
U.S. Renal Care Achieves 75% Site Adoption Of eConsent
By dispelling prevalent misconceptions regarding participant age, cost, and complexity, see how this platform emerged as a versatile, rapid, and effective solution tailored to the unique needs of the elderly renal care population.
-
Use Case: How Consulting & Analytics Can Guide Clinical Strategy
A large European pharmaceutical company sought to benchmark a CRO’s suggestions involving a Phase III trial for a newly acquired asset.
-
Innovation Under Pressure: Navigating Clinical Trials Amid a Pandemic
How do you complete a Phase 2b rheumatology study in three countries despite global lockdowns? Palleos cracked the code, achieving recruitment targets and regulatory approvals against all odds.
NEWS
-
U.S. Department Of Energy Announces $6.9M In Projects To Support Effective Community Waste-To-Energy Strategies For Local Transportation Needs1/7/2025
The U.S. Department of Energy's (DOE) Bioenergy Technologies Office (BETO) and Vehicle Technologies Office (VTO) announced $6.9M in funding for nine projects to support local waste-to-energy management solutions for transportation energy needs.
-
The Persistence Of PFAS - IDTechEx Covers Growing PFAS Regulations4/24/2025
Per- and polyfluoroalkyl substances (PFAS) are a broad group of chemicals that includes both polymers and non-polymers used in many applications, from transport to consumer products.
-
Stoichiometric Crystal Shows Promise In Quantum Memory7/7/2025
For over two decades, physicists have been working toward implementing quantum light storage—also known as quantum memory—in various matter systems.
-
Smarter Dentistry Starts Here: Muskan.AI Enhances Diagnostics, Imaging & Patient Care5/19/2025
Muskan.AI, a pioneer in the application of artificial intelligence to dentistry, has reached several key milestones in its mission to transform dental care through intelligent, accessible, and clinician-focused technology.
-
NX Filtration And Eau d'Azur Partner For Advanced Micropollutant Treatment In Nice8/25/2025
NX Filtration, a global leader in advanced hollow fiber membrane technology, is proud to announce its collaboration with Eau d’Azur, the public company responsible for drinking water and wastewater services for the Nice Côte d'Azur Metropole.
ABOUT
Harvest and Collection
Harvest and collection is the process used to retrieve biological agents and vaccines present in cell cultures or to harvest and collect stem cells from blood or bone marrow. Many bioresearch companies have sophisticated systems for harvesting and collecting cells. These systems make counting cells easier and they also protect against contamination.
Cells are harvested once the cells reach a density level in the cell culture medium that precludes further growth. The best time to harvest cells is when they are in a confluent state (at least 50% of the culture dish is covered and before 100% of the dish is covered).
Cells can be harvested using on of three methods: Mechanical, using Proteolytic enzymes, or using EDTA. Mechanical harvesting uses a rubber spatula to remove the cells from the growth surface or culture. This method is quick but can cause many cells to die because it is highly disruptive. This method is favored when harvesting lots of different samples of cells to prepare extracts.
In this case, viability of the cells doesn’t matter. Three enzymes; Trypsin, Collagenase, and Pronase can be used in combination with EDTA. The combination of these enzymes with the EDTA makes cells detach from the growth medium.
This method is easy but also has a downside. It can damage the cell surface by eating up exposed cell surface proteins. EDTA can be used alone to detach cells from their medium and it is gentler than using trypsin.
Normally, collected cells are placed in a new suspension, or growth medium to continue growing new cultures. This is referred to as passaging or splitting the cells.