Harvest & Collection
PRODUCTS
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![iStock-1293772874-lab-plasmid-gene therapy-DNA]( "Plasmid DNA Manufacturing Service")
Plasmid DNA manufacturing using a unique process for Research, HQ and GMP grades
Benefits
- Purity- High purity plasmids with very low endotoxin level (< 2EU/mg)
- Robust- Unique scalable proprietary process allowing plasmid production from 50mg to 20g in Research, HQ & GMP grades
- Time-Saving- Between 4 and 7 weeks for Research Grade and 3 months for GMP grade
- Flexible- Manufacturing process compatible with all types of plasmids (from 2 to more than 20 kb, plasmids for LV, AAV, mRNA)
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![fireant]( "FireAnt HD SWIR")
The FireAnt HD SWIR lens is a low SWaP-C solution, suitable for a range of applications. The unique single aperture design, coupled with folded geometry, delivers a short track length and small physical footprint, enabling one gimbal window to accommodate multiple sensors and SWIR imaging to be combined with other bands in one package.
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![SCIEX M5 MicroLC System]( "SCIEX M5 MicroLC System")
See More with Microflow LC-MS
The M5 MicroLC system is the perfect balance of sensitivity and robustness—more sensitive than traditional analytical flow LC, and more flexible and more robust than nanoflow LC — giving you the potential to optimize your critical workflows, today and into the future.
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![rtp-oscilloscope-front-low-rohde-schwarz_200_53660_1024_576_13]( "R&S®RTP Oscilloscope")
The R&S®RTP high-performance oscilloscope combines high-class signal integrity with a fast acquisition rate. Customized frontend ASIC and real-time processing hardware enable highly accurate measurements with unprecedented speed in a compact form factor.
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![allegro-family]( "Allegro Technology By Master Meter")
At Master Meter, we believe that a combination of different underlying communication technologies, which share a common endpoint design is a highly efficient and cost-effective approach. That’s why we’ve developed a a flexible smart water technology solution for advanced water utility management.
Allegro Technology addresses issues that utilities often face when implementing AMI, regardless of a particular utility’s nuances and deployment needs. Allegro’s end-to-end solid-state technology optimizes project outcomes and business deliverables to help utilities solve their toughest water management challenges.
WHITE PAPERS AND CASE STUDIES
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![GettyImages-1295902079 budget]( "Professional Services Expedite Hospital's Study Process")
Professional Services Expedite Hospital's Study ProcessExplore the details of a transformative partnership where a children's hospital was able to overcome coverage analysis and budget negotiation issues despite a significant staff turnover.
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![laptop document iStock-1188431918.jpg]( "Harnessing Critical Experience To Plan And Execute A Dual-Submission Study")
Harnessing Critical Experience To Plan And Execute A Dual-Submission StudyPoint-of-care (POC) tests offer significant convenience for patients and physicians, as well as cost savings for payers. Yet, achieving regulatory approval can be daunting. Discover how a clear strategy was developed to ensure that the necessary data to support both 510(k) clearance and CLIA waiver would be collected within a single clinical trial.
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![iStock-136140244-lab-pharma-equipment-process]( "Speed To Market – API Large-Scale Commercial Manufacturing")
Speed To Market – API Large-Scale Commercial ManufacturingA pharmaceutical company was looking to partner with a CMO with commercial manufacturing capabilities, large-scale assets, multinational sites, and exemplary quality systems/U.S. FDA track record.
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![Whiskey GettyImages-533957701]( "Increase Capacity And Improve Consistency By Replacing Flat Sheet Filtration")
Increase Capacity And Improve Consistency By Replacing Flat Sheet FiltrationLearn how a large distillery that produces several million liters of various brands of Canadian whisky achieved cost-effective and quality-enhancing filtration with SUPRApak technology for distilled spirits production.
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![GettyImages-627582858-strategic-partnerships]( "Discover A Reference Control Alternative To HIV+ Donor Samples")
Discover A Reference Control Alternative To HIV+ Donor SamplesA Fortune 100 pharmaceutical company found success in addressing their HIV treatment research challenges through a partnership that provided them with a p24-expressing, non-infectious synthetic T cell mimic.
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![Embryonic Stem Cells GettyImages-1135352068]( "Using A Fixed Bed Reactor System For Expansion Of Human Embryonic Stem Cells")
Using A Fixed Bed Reactor System For Expansion Of Human Embryonic Stem CellsRegenerative medicine company ViaCyte Inc. explored new technologies to enable expanded scales of culturing hESCs for development of cell replacement therapies as a functional cure for Type 1 diabetes.
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![GettyImages-1134462016 CRO agility]( "Achieving Healthy CRO Growth Through Agility")
Achieving Healthy CRO Growth Through AgilityDiscover how George Clinical, a contract research organization based in Sydney, Australia, achieved robust CRO growth by harnessing the power of agility with Merative.
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![Chrom-Campaign-LSC-V6-Newsletter-B-450x300px]( "Optimizing End-To-End Processes To Reduce Costs And Improve Yields")
Optimizing End-To-End Processes To Reduce Costs And Improve YieldsExplore the challenges faced by a large CDMO as well as the solutions that were provided to achieve significant time savings, cost savings, and the removal of a major downstream process limitation.
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![GettyImages-1372189785 waiting room]( "Study Completes Recruitment, Overcomes Pandemic Hurdles")
Study Completes Recruitment, Overcomes Pandemic HurdlesAmid challenges during the COVID-19 pandemic, discover how recruitment was completed in three countries for a Sweden-based pharmaceutical company's phase 2b study.
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![gettyimages-1326140128-170667a]( "Tank Terminal Wastewater Treatment")
Tank Terminal Wastewater TreatmentIn this case study, explore the results of Aquacycl's installation of a pilot-scale BETT system to treat a side-stream of wastewater from a tank terminal operator's facility.
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![GettyImages-1206365639 consent]( "Research Site Network Enhances Study Startup With Reliable ICF Writing Services")
Research Site Network Enhances Study Startup With Reliable ICF Writing ServicesWith help from a new informed consent form (ICF) writing partner, discover how CenExel Clinical Research was able to streamline processes and launch new studies faster.
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![submersible-mixer]( "Sulzer Mixers Designed To Tackle Digested Sludge")
Sulzer Mixers Designed To Tackle Digested SludgeDiscover how a wastewater treatment plant solved its mixing problem that was caused by the high sludge content.
NEWS
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Government Of Canada Taking Next Step In Addressing ‘Forever Chemicals’ PFAS5/19/2023
The Government of Canada is committed to protecting the health and safety of Canadians and the environment from the effects of chemical substances.
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U.S. Government Accredits GlobalFoundries To Manufacture Trusted Semiconductors At New York Facility5/30/2023
The U.S. Department of Defense (DoD), through the Defense Microelectronics Activity (DMEA), Trusted Access Program Office (TAPO), has accredited GlobalFoundries’ (Nasdaq: GFS) (GF) advanced manufacturing facility in Malta, New York, as a Category 1A Trusted Supplier with the ability to manufacture secure semiconductors for a range of critical aerospace and defense applications.
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Ultrashort Light Pulses Shaped Like A Spring Toy Bring A New Twist In Photonics6/8/2023
An international team of researchers, led by Marco Piccardo, a former researcher at the Italian Institute of Technology (IIT) and now a Professor in the Physics Department of Técnico Lisboa and Principal Investigator at the Engineering Institute for Microsystems and Nanotechnologies (INESC MN), has harnessed ultrafast optics and structured light to synthesize in the laboratory a new family of spatiotemporal light beams, known as light springs
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UC Irvine Engineers Invent A Way To 3D Print Optical-Grade Glass At The Nanoscale6/6/2023
A research team led by scientists at the University of California, Irvine has developed a new low-temperature method for 3D printing optical-grade glass, opening the door for microelectronic systems with high-resolution, visible-light nanophotonics capabilities.
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Asure Harnesses AI To Reinforce HR Compliance Service Scalability And Improve Client Interactions5/17/2023
Asure Software (NASDAQ: ASUR), an established provider of cloud-based Human Capital Management (HCM) software solutions, has incorporated artificial intelligence (AI) to amplify scalability in its human-led HR compliance services.
ABOUT
Harvest and Collection
Harvest and collection is the process used to retrieve biological agents and vaccines present in cell cultures or to harvest and collect stem cells from blood or bone marrow. Many bioresearch companies have sophisticated systems for harvesting and collecting cells. These systems make counting cells easier and they also protect against contamination.
Cells are harvested once the cells reach a density level in the cell culture medium that precludes further growth. The best time to harvest cells is when they are in a confluent state (at least 50% of the culture dish is covered and before 100% of the dish is covered).
Cells can be harvested using on of three methods: Mechanical, using Proteolytic enzymes, or using EDTA. Mechanical harvesting uses a rubber spatula to remove the cells from the growth surface or culture. This method is quick but can cause many cells to die because it is highly disruptive. This method is favored when harvesting lots of different samples of cells to prepare extracts.
In this case, viability of the cells doesn’t matter. Three enzymes; Trypsin, Collagenase, and Pronase can be used in combination with EDTA. The combination of these enzymes with the EDTA makes cells detach from the growth medium.
This method is easy but also has a downside. It can damage the cell surface by eating up exposed cell surface proteins. EDTA can be used alone to detach cells from their medium and it is gentler than using trypsin.
Normally, collected cells are placed in a new suspension, or growth medium to continue growing new cultures. This is referred to as passaging or splitting the cells.