Harvest & Collection
PRODUCTS
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![Repligen - XCell]( "XCell® ATF System")
Simplify and intensify upstream bioprocessing. The XCell® ATF System, in single-use or stainless steel format, delivers superior cell retention. High impact upstream applications include N-1 perfusion, high productivity harvest, long-term perfusion and seed train intensification.
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![GettyImages-1425605790 Life Sciences Training. Scientists Using A Computer In A Lab]( "Qualified Person (QP) Services")
Providing around-the-clock support, enabled by at least two QPs per assignment, delivering full continuity, and reduced risk.
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![Mettler-Toledo - X12]( "X-Ray Inspection System: X12")
High-performance x-ray inspection system that delivers improved product quality and increased product safety. The X12 system is the perfect solution for small-medium food and pharmaceutical products.
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![GettyImages-1300884716]( "Highly Precise Large Optics")
Discover PG&O's expertise in precision polishing & coating for large format optics up to 30", delivering exceptional flatness & surface quality.
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![Europe iStock-490822468]( "European Regulatory Development")
Scientific knowledge to strategize viable and efficient drug and device development pathways to achieve successful outcomes.
WHITE PAPERS AND CASE STUDIES
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![HOD UV positioned at the outlet of the PW tank]( "Disinfection For Purified Water Loop For Kamada Pharmaceuticals, Israel")
Disinfection For Purified Water Loop For Kamada Pharmaceuticals, IsraelAn Atlantium HOD™ (Hydro-Optic Disinfection) UV system was installed at the outlet of a PW tank to serve as the primary disinfection barrier, with water circulating through the system at 6m³/hr before reaching the points of use.
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![GettyImages-1987435635 research, planning]( "Rescuing A Global Program For NDA Success")
Rescuing A Global Program For NDA SuccessExplore the collaboration that enabled FDA approval of a novel chronic-condition therapy, rescued a high-risk program, and demonstrated a unified “one-team” approach by reworking the sponsor's SAP.
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![Laser GettyImages-1311236338]( "Thales Receives Custom 10PW Beam Dump For World's Most Powerful Laser")
Thales Receives Custom 10PW Beam Dump For World's Most Powerful LaserBy collaborating with Gentec-EO and their distributor Laser Components, see how Thales was able to gather the necessary specifications and requirements for this project.
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![Developing mRNA Vaccines GettyImages-1307593959]( "Improving Pre-Clinical Study Efficiency With mRNA-LNP Technology")
Improving Pre-Clinical Study Efficiency With mRNA-LNP TechnologyUncover how Repair Biotechnologies, in collaboration with Vernal Biosciences, helped to pave the way for the next generation of breakthrough treatments for cholesterol and aging-related diseases.
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![GettyImages-1819626829 patient recruitment]( "A Community-Focused Approach To Metabolic Disease Trials")
A Community-Focused Approach To Metabolic Disease TrialsLearn how innovative strategies like free health exams, community engagement, and a comprehensive patient database helped this project achieve rapid enrollment with a high level of patient diversity.
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![Operator loading nested vials into Microcell vial filler]( "CDMO Uses Robotic Gloveless Isolator For Advanced Therapeutics")
CDMO Uses Robotic Gloveless Isolator For Advanced TherapeuticsCDMOs must innovate production architectures to meet the demands of advanced therapeutics to ensure a reliable supply and compliance. Discover how these approaches advance modern medicine and improve patient outcomes.
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![Digital Checklist GettyImages-1465188429]( "Using Virtual Study Coordinators For EDC Entry And Query Resolution To Speed Up Data Access And Cleaning")
Using Virtual Study Coordinators For EDC Entry And Query Resolution To Speed Up Data Access And CleaningThe piece showcases how the effective use of CRIO can significantly enhance site performance, supporting recruitment and diversity objectives for sponsors.
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![AI Robotic brain-GettyImages-2210997075]( "Changing The Clinical Feasibility Game With AI")
Changing The Clinical Feasibility Game With AIAI is only as good as the data it’s built upon. Our customized AI platforms are constructed on a foundation of trustworthy, carefully curated data to produce detailed, expert-driven responses.
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![HOD-UV-chile]( "RO Membrane Protection For A Desalination Plant In Mejillones, Chile")
RO Membrane Protection For A Desalination Plant In Mejillones, ChileRead about a seawater desalination plant that presented with several performance issues and chose the HOD UV system to control biofouling on the RO membranes.
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![regeneron-cgmp-gowning-cleanroom-5]( "Mobile Gowning Cleanroom, Built To Meet ISO 7 Requirements")
Mobile Gowning Cleanroom, Built To Meet ISO 7 RequirementsUncover how Germfree designed and installed a mobile cGMP cleanroom on a 53′ tractor-trailer chassis to provide a flexible and efficient cleanroom solution tailored to the company’s needs.
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![Nova Benchtop]( "Transferring From Microfluidics To A Turbulent Mixer")
Transferring From Microfluidics To A Turbulent MixerWhat solutions did the client featured in this case study find when they sought help in transferring their formulation process to a turbulent Impinged Jet Mixing (IJM)?
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![Laminar Flow Glovebox Isolator LFGI]( "CAR-T And Laminar Flow Glovebox Isolators")
CAR-T And Laminar Flow Glovebox IsolatorsA request was made for a containment system that would protect operators during lentivirus transfer, as well as provide a controlled environment for IL-2 charging of media, bead addition, and blood bag spiking.
NEWS
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ZEISS Introduces The New Smartzoom 100: The Future Of Digital Microscopy For Efficient Optical Inspections5/6/2025
ZEISS presents the new ZEISS Smartzoom 100, an innovative digital microscope for fast and efficient quality assurance.
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Meatable And TruMeat Collaborate To Accelerate Cost-Effective Cultivated Meat Production4/30/2025
Meatable, the leader in cultivated meat technology, and TruMeat, specializing in the contract manufacturing of cultivated meat at commercial scale, have formed a strategic collaboration to advance the global commercialization of cultivated meat.
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KBR Expands Support For Saudi's Energy Future1/22/2025
KBR announced today it has been awarded a contract to support sustainable production of energy resources in Saudi Arabia by contributing to the delivery of Saudi Aramco’s Master Expansion Program and increasing gas handling capacity at key regional locations.
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PNE Group Receives Permits For Three New Wind Farms In Germany7/8/2025
In the second quarter of 2025, the PNE Group received the necessary permits for the construction and operation of three onshore wind farms in the German states of Brandenburg, Hesse, and North Rhine-Westphalia.
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SJW Infrastructure Improvement Progressing At Cambrian Tank Replacement Project5/29/2025
San Jose Water (“SJW” or “the Company”), a wholly owned subsidiary of H2O America, has made meaningful progress on its Cambrian Tank Replacement project, a major investment in the long-term reliability and seismic resilience of the Company’s water system.
ABOUT
Harvest and Collection
Harvest and collection is the process used to retrieve biological agents and vaccines present in cell cultures or to harvest and collect stem cells from blood or bone marrow. Many bioresearch companies have sophisticated systems for harvesting and collecting cells. These systems make counting cells easier and they also protect against contamination.
Cells are harvested once the cells reach a density level in the cell culture medium that precludes further growth. The best time to harvest cells is when they are in a confluent state (at least 50% of the culture dish is covered and before 100% of the dish is covered).
Cells can be harvested using on of three methods: Mechanical, using Proteolytic enzymes, or using EDTA. Mechanical harvesting uses a rubber spatula to remove the cells from the growth surface or culture. This method is quick but can cause many cells to die because it is highly disruptive. This method is favored when harvesting lots of different samples of cells to prepare extracts.
In this case, viability of the cells doesn’t matter. Three enzymes; Trypsin, Collagenase, and Pronase can be used in combination with EDTA. The combination of these enzymes with the EDTA makes cells detach from the growth medium.
This method is easy but also has a downside. It can damage the cell surface by eating up exposed cell surface proteins. EDTA can be used alone to detach cells from their medium and it is gentler than using trypsin.
Normally, collected cells are placed in a new suspension, or growth medium to continue growing new cultures. This is referred to as passaging or splitting the cells.