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FEATURED ARTICLES
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![GettyImages-1182436133 scientist, lab, research, oncology]( "Precision In Nanoparticle Processing And Monodispersed Lipid Nanoparticles For Advanced Therapeutics")
Precision In Nanoparticle Processing And Monodispersed Lipid Nanoparticles For Advanced TherapeuticsPrecision in nanoparticle processing is key for drug delivery and vaccines. Learn how monodispersed formulations enhance reproducibility and stability for next-generation therapeutics, like RNA-LNPs.
WHITE PAPERS & CASE STUDIES
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![Assessing Particle Generation In A Single-Use Mixing System]( "Assessing Particle Generation In A Single-Use Mixing System")
Assessing Particle Generation In A Single-Use Mixing SystemExplore how particle levels remained stable during 24 hours of high-speed mixing, even under extreme temperatures, confirming a system’s suitability for final fill and other particulate-sensitive applications.
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![GettyImages-1214112149-lab-team-collaboration-research]( "Your Guide To Precise And Robust Separation Methods")
Your Guide To Precise And Robust Separation MethodsDiscover a detailed guide to characterizing GLP-1 receptor agonists that covers advanced LC-MS and SEC-MALS workflows for impurity profiling, stability testing, and aggregate analysis.
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![GettyImages-1401910116 green fluorescent proteins]( "Generate CHO-K1 GFP-Expressing Cells For Cell Line Development Workflow")
Generate CHO-K1 GFP-Expressing Cells For Cell Line Development WorkflowDiscover a high-efficiency workflow for generating GFP-expressing CHO-K1 clones using automated single-cell dispensing to achieve 93% isolation success and stable expression in under five weeks.
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![GettyImages-1609550431-96 well micro plate and pipettes]( "Simplify Cell Line Development")
Simplify Cell Line DevelopmentA streamlined workflow combining microfluidic dispensing and multimodal imaging enables efficient single-cell isolation, viability assessment, and outgrowth analysis to support cell line development.
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![Researcher at work in DNA genetic laboratory, virus and pathogen detection-GettyImages-1346857647]( "A Universal Workflow Approach For Single Cell Mass Spectrometry Based Proteomics")
A Universal Workflow Approach For Single Cell Mass Spectrometry Based ProteomicsLearn about a streamlined workflow that improves reproducibility, reduces contamination, and simplifies single-cell proteomics with comparable results to FACS.
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![GettyImages-2223536069 protein]( "Enable Low Volume Delivery Of Proteins In Aqueous Solutions")
Enable Low Volume Delivery Of Proteins In Aqueous SolutionsAchieve ultra-low volume dispensing of proteins and aqueous solutions without surfactants with consistent precision, minimal contamination, and broad compatibility to streamline your lab workflow.
PRODUCTS & SERVICES
Whether you're looking to boost performance, enhance your capabilities, or simply get consistent, high-quality results, HyClone™ peak expression medium and HyClone™ prime expression medium are the solutions for you.
The LevMixer™ 10 L single-use mixing system is a low volume mixer designed for both upstream and downstream applications.
DIANT Pharma provides continuous manufacturing systems and technical services for nanoparticle-based formulations. The company’s platform supports both research and manufacturing teams working on lipid nanoparticles (LNPs), liposomes, polymeric micelles, nucleic acid–lipid complexes, and other colloidal systems.
Sterility is key for high-risk applications such as injectables, parenteral formulations, ophthalmic and peritoneal dialysis solutions, and many more.
Developing nanoparticle formulations requires a scalable solution that replicates manufacturing conditions at a small scale. Turbulent jet mixing enables linear scalability while conserving materials.
Enabling you to design vaccines without reliance on animal sources with our fermentation-produced squalene.
Immersion corrosion testing is a method used to determine the rate of corrosion of a test article, often a metal, in aqueous solution. Though this test can be used as an assessment tool for many applications, it is commonly used to evaluate the corrosivity of liquids.
Accelerate your drug development with our comprehensive pre-formulation, formulation, and novel delivery system expertise, tailored to optimize physical form, enhance solubility, and support scale-up.
ABOUT
Formulation
Formulation in bioresearch is directly associated with pharmaceutical research and development. It is the practice of combining different chemical substances that include the active medical drug. This combination of drug and chemicals is tweaked until they have a final medicinal formulation that can be tested and receive final approval for large-scale market use.
The object of pre-formulation and formulation is to develop a stable preparation of a specific drug that is acceptable for human consumption. All drugs, by necessity, contain other chemicals. In order to put a drug into a capsule or tablet form it requires a variety of substances other than the drug itself. Formulation is needed to ensure that the drug will work when combined with these other substances.
It may surprise you to know that most formulations are not complete until after Phase III clinical trials are in progress or completed. All the early trials test drug stability, and drug load, which is the ratio of active drug to the total content of the actual dose.
Formulation studies address a variety of issues includinggrain size, pH (acidic or alkaline), solubility, and polymorphism (the ability of a drug to exist in more than one form like liquid and capsule). Other items formulation addresses is taste, appearance, tablet hardness and tablet or capsule disintegration.
Another aspect of formulation is testing how humidity, temperature, oxidation, ultraviolet light or visible light affects the formulation. The formula must be stable and not degrade under all of the different environmental factors.
Formulation involves a lot of experimenting with different blends of materials and drugs, but is absolutely crucial for the development of effective, safe, stable, oral drugs, and topical ointments.