bio-formulation-995x60
FEATURED ARTICLES
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![GettyImages-675822772-scientist-holding-book-with-bioreactor]( "In Vivo Manufacturing: When The Body Becomes The Bioreactor")
In Vivo Manufacturing: When The Body Becomes The BioreactorBreakthrough therapies are reshaping medicine, but manufacturing complexity is holding them back. Discover how rethinking production and delivery could expand reach and improve patient experience.
WHITE PAPERS & CASE STUDIES
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![pharma-manufacturing-GettyImages-2196233628]( "Effect of Shelf Cooling Rate on the Nucleation Temperature of Ice Monitored Using Thermocouples and Wireless Temperature Sensors")
Effect of Shelf Cooling Rate on the Nucleation Temperature of Ice Monitored Using Thermocouples and Wireless Temperature SensorsFreezing conditions shape ice structure, mass transfer resistance, and drying efficiency. Data shows how cooling rate, vial size, and nucleation interact to optimize freeze-drying.
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![GettyImages-1218315246-rheometer-lab-scientist-hand]( "Predicting Performance Of Lotions Through Rheological Characterization")
Predicting Performance Of Lotions Through Rheological CharacterizationRheological testing shows how small formulation differences influence spreading, flow, and feel during use. With minimal sample volumes, these methods connect lab measurements to real‑world performance.
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![GettyImages-1218315283-scientist-rheometer-lab]( "Rheology Is An Accurate Predictor Of Pharmaceutical Lotion Stability")
Rheology Is An Accurate Predictor Of Pharmaceutical Lotion StabilityRheological creep testing provides a rapid way to predict pharmaceutical lotion stability by linking steady-state viscosity to particle settling behavior, enabling reliable shelf-life estimates.
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![GettyImages-950086574-microscope-scientist-pill-development]( "Why Pharmaceutical Scientists Trust The Discovery Core Rheometer")
Why Pharmaceutical Scientists Trust The Discovery Core RheometerDrug formulations demand more than single‑point viscosity data. Explore how rheology reveals stability, flow, and structural behavior across suspensions, topicals, and injectables.
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![GettyImages-1213680755-scientist-gloves-assay-cell-culture]( "Bispecific T- Cell Engager (BiTE) Screening, Automated Pipeline")
Bispecific T- Cell Engager (BiTE) Screening, Automated PipelineView automated, high‑throughput BiTE screening in mammalian cells, enabling rapid discovery of efficacious variants through precise genomic integration and scalable workflows.
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![RNA, ribonucleic acid-GettyImages-2195556279]( "De-Risk Nucleic Acid Therapeutics Through Strategic Outsourcing")
De-Risk Nucleic Acid Therapeutics Through Strategic OutsourcingBringing a nucleic acid therapy to market requires specialized formulation and development knowledge. Innovators need rigorous analytical and formulation strategies to achieve stability and quality.
PRODUCTS & SERVICES
Unused 30 Sq Meter Optima Pharma Freeze Dryer Lyophilizer, Model FD S-30, stainless steel construction, (13) usable shelves, 1520mm x 1520mm, 120mm shelf spacing, stoppering, job# 4039023, built 2020. Unit was never installed still on original shipped skids from manufacturer.
Whether you're looking to boost performance, enhance your capabilities, or simply get consistent, high-quality results, HyClone™ peak expression medium and HyClone™ prime expression medium are the solutions for you.
The LevMixer™ 10 L single-use mixing system is a low volume mixer designed for both upstream and downstream applications.
DIANT Pharma provides continuous manufacturing systems and technical services for nanoparticle-based formulations. The company’s platform supports both research and manufacturing teams working on lipid nanoparticles (LNPs), liposomes, polymeric micelles, nucleic acid–lipid complexes, and other colloidal systems.
Simple, scalable genome engineering at the naturally occurring S-SELeCT™ safe harbor locus.
Build cell-based models of disease and accelerate therapeutic development with TARGATT™ large knock-in technology in iPSCs.
Sterility is key for high-risk applications such as injectables, parenteral formulations, ophthalmic and peritoneal dialysis solutions, and many more.
Developing nanoparticle formulations requires a scalable solution that replicates manufacturing conditions at a small scale. Turbulent jet mixing enables linear scalability while conserving materials.
ABOUT
Formulation
Formulation in bioresearch is directly associated with pharmaceutical research and development. It is the practice of combining different chemical substances that include the active medical drug. This combination of drug and chemicals is tweaked until they have a final medicinal formulation that can be tested and receive final approval for large-scale market use.
The object of pre-formulation and formulation is to develop a stable preparation of a specific drug that is acceptable for human consumption. All drugs, by necessity, contain other chemicals. In order to put a drug into a capsule or tablet form it requires a variety of substances other than the drug itself. Formulation is needed to ensure that the drug will work when combined with these other substances.
It may surprise you to know that most formulations are not complete until after Phase III clinical trials are in progress or completed. All the early trials test drug stability, and drug load, which is the ratio of active drug to the total content of the actual dose.
Formulation studies address a variety of issues includinggrain size, pH (acidic or alkaline), solubility, and polymorphism (the ability of a drug to exist in more than one form like liquid and capsule). Other items formulation addresses is taste, appearance, tablet hardness and tablet or capsule disintegration.
Another aspect of formulation is testing how humidity, temperature, oxidation, ultraviolet light or visible light affects the formulation. The formula must be stable and not degrade under all of the different environmental factors.
Formulation involves a lot of experimenting with different blends of materials and drugs, but is absolutely crucial for the development of effective, safe, stable, oral drugs, and topical ointments.