bio-formulation-995x60
FEATURED ARTICLES
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![Key to success-GettyImages-172169551]( "Unlocking Method Insights For Novel Engineered AAV Capsids")
Unlocking Method Insights For Novel Engineered AAV CapsidsMicrofluidic platforms, such as labchip, are widely used for assessing wild type capsids. Now, engineered capsids are challenging these established workflows.
WHITE PAPERS & CASE STUDIES
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![GettyImages-1371925389-lab-scientist-collaboration-computer-clipboard]( "Overcoming Excipient Risks And Challenges For Parenteral Formulations")
Overcoming Excipient Risks And Challenges For Parenteral FormulationsExcipients are essential to parenteral formulations, which help protect APIs, enhance stability, and ensure safety. Learn how strategic excipient selection can optimize drug performance and patient outcomes.
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![Stabilization Of RNA-Loaded Lipid Nanoparticles By Lyophilization]( "Stabilization Of RNA-Loaded Lipid Nanoparticles By Lyophilization")
Stabilization Of RNA-Loaded Lipid Nanoparticles By LyophilizationDiscover how lyophilization enhances RNA-based therapeutics by enabling storage at higher temperatures, which simplifies cold-chain logistics while preserving nanoparticle integrity and biological activity.
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![GettyImages-2174865889 lab, research]( "Tangential Flow Filtration Of LNPs Results In 10X Concentration Within 20 Minutes")
Tangential Flow Filtration Of LNPs Results In 10X Concentration Within 20 MinutesDive into a study that details how a single-pass tangential flow filtration system can achieve a tenfold concentration of liposomal nanoparticles in under 20 minutes.
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![GettyImages-664557312 microscpe, lab, research, analysis, assay]( "Enhanced Structural Characterization Of Thermal Unfolding With MMS")
Enhanced Structural Characterization Of Thermal Unfolding With MMSExplore the power of Microfluidic Modulation Spectroscopy (MMS) in resolving distinct melting behaviors and domain-specific unfolding events for biologics, providing crucial structural insights for development and formulation.
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![GettyImages-1403976499-scientist-pharma-manufacturing-vaccine]( "Non Animal Origin Squalene For High-Risk Applications")
Non Animal Origin Squalene For High-Risk ApplicationsExplore an ethical and sustainable alternative to shark-derived squalene that is backed by robust data to deliver identical performance in vaccine formulations without environmental compromise.
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![GettyImages-2178829362 GLP-1]( "Structural Characterization Of GLP-1 Analogues And Formulations Using MMS")
Structural Characterization Of GLP-1 Analogues And Formulations Using MMSDiscover how MMS quantifies peptide concentrations and identifies structural differences in GLP-1 and its commercial analogues across various buffer systems.
PRODUCTS & SERVICES
Sterility is key for high-risk applications such as injectables, parenteral formulations, ophthalmic and peritoneal dialysis solutions, and many more.
Developing nanoparticle formulations requires a scalable solution that replicates manufacturing conditions at a small scale. Turbulent jet mixing enables linear scalability while conserving materials.
Enabling you to design vaccines without reliance on animal sources with our fermentation-produced squalene.
Immersion corrosion testing is a method used to determine the rate of corrosion of a test article, often a metal, in aqueous solution. Though this test can be used as an assessment tool for many applications, it is commonly used to evaluate the corrosivity of liquids.
Accelerate your drug development with our comprehensive pre-formulation, formulation, and novel delivery system expertise, tailored to optimize physical form, enhance solubility, and support scale-up.
Research Use Only (RUO) lipid nanoparticle (LNP) reagents to deliver RNA into hematopoietic stem cells (HSCs) for cell and gene therapy applications.
Off-the-shelf, research use only lipid nanoparticle (LNP) reagents to deliver RNA into T-cells.
Ideal tool for characterizing nanoparticles
The Corning Videodrop utilizes the principles of interferometry in conjunction with microscopy to sense, detect, characterize, and track single nanoparticles in real time. The operation of this bioproduction analytical device is seamless thanks to its intuitive software interface and efficient sample handling protocol.
ABOUT
Formulation
Formulation in bioresearch is directly associated with pharmaceutical research and development. It is the practice of combining different chemical substances that include the active medical drug. This combination of drug and chemicals is tweaked until they have a final medicinal formulation that can be tested and receive final approval for large-scale market use.
The object of pre-formulation and formulation is to develop a stable preparation of a specific drug that is acceptable for human consumption. All drugs, by necessity, contain other chemicals. In order to put a drug into a capsule or tablet form it requires a variety of substances other than the drug itself. Formulation is needed to ensure that the drug will work when combined with these other substances.
It may surprise you to know that most formulations are not complete until after Phase III clinical trials are in progress or completed. All the early trials test drug stability, and drug load, which is the ratio of active drug to the total content of the actual dose.
Formulation studies address a variety of issues includinggrain size, pH (acidic or alkaline), solubility, and polymorphism (the ability of a drug to exist in more than one form like liquid and capsule). Other items formulation addresses is taste, appearance, tablet hardness and tablet or capsule disintegration.
Another aspect of formulation is testing how humidity, temperature, oxidation, ultraviolet light or visible light affects the formulation. The formula must be stable and not degrade under all of the different environmental factors.
Formulation involves a lot of experimenting with different blends of materials and drugs, but is absolutely crucial for the development of effective, safe, stable, oral drugs, and topical ointments.