Expert Insights On Cell Line Development

1. The Hidden Engineering Behind Successful Upstream Bioprocessing 2/25/2026

   In upstream biopharmaceutical production, manufacturing is inseparable from biology, engineering, contamination control, and quality science.

2. This Industrial Fungus Has Protein Expression Promise For Pharma 2/12/2026

   Trichoderma reesei is well characterized for industrial uses. A Finnish research group is exploring it for pharmaceutical protein expression.

3. High Specific Productivity For Leaner Sustainable Bioprocessing 1/30/2026

   Improving specific productivity moves the goal beyond pumping out higher titers, but it demands a deeper understanding of cellular biology and protein expression.

4. Why Use Total Organic Carbon Analysis For Cleaning Validation? 1/21/2026

   Total organic carbon analysis is probably the most “fit for use” analytical method to validate cleaning processes, particularly within a science- and risk-based approach.

5. Ask The Pros — The Latest In Upstream HCP Mitigation 1/5/2026

   We asked leading experts how upstream interventions can reshape HCP control. Here’s what they shared. Answers have been edited for clarity.

6. An End-To-End Automated HTP Platform For Cell Line Optimization 11/20/2025

   Bristol Myers Squibb's high-throughput stable CHO platform produces high-titer, high-quality material in a fraction of the conventional timeline.

7. How To Grow CHO Cells Without Cysteine, Tyrosine Feeds 9/19/2025

   Researchers at Pfizer are developing a cell line that synthesizes these amino acids autonomously, which could reduce costs and increase stability.

8. Cleaning Process Capability: Risk-Based Cleaning Process Performance Qualification 7/1/2025

   A cleaning validation professional must know how many process performance qualification runs are necessary. Here's how to go about demonstrating this with a high degree of assurance while minimizing the number of qualification runs.

9. Why 'Which Is Best?' Is The Wrong Question In CGT Development 6/27/2025

   In cell therapy development, the instinct to seek a single “best” option is natural — but in reality, there’s rarely a universal winner.

10. Cleaning Process Capability: Understanding Populations, Samples, And Sample Size Requirements 6/6/2025

    This article examines the role of sample sizes in the determination of cleaning process capability or process performance in the manufacture of drugs/therapies and medical devices.