
ABOUT US
PBS Biotech (Camarillo, CA, USA) was founded in 2006 and is a leading global provider of single-use bioreactor systems and process development services (such as seeding, expansion, harvesting, detachment, cell separation, washing, and concentration) for the cell therapy industry.
PBS Biotech single-use bioreactors utilize patented Vertical-Wheel Impeller technology, which provides research scientists with a scalable platform (0.1L to 80L) optimized for cell therapy manufacturing requirements. Allowing scientists to streamline their process development and accelerate their time to market. Numerous published studies have confirmed the superior mixing performance and scalability of Vertical-Wheel Impeller technology when compared to traditional stirred-tank bioreactors, particularly for applications involving induced pluripotent stem cells (iPSCs) grown as aggregates or mesenchymal stem cells (MSCs) grown on microcarriers.
PBS Biotech single-use bioreactors enable the manufacturing of allogeneic therapies derived from cells such as induced pluripotent stem cells, mesenchymal stem cells, and CAR-T or NK cells and empower scientists to develop cell therapy products that combat debilitating diseases such as cancer, diabetes, and heart failure.
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FEATURED INSIGHTS
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Explore how computational fluid dynamics (CFD) characterize and scale-up vertical-wheel bioreactors, optimizing hydrodynamic conditions for effective induced pluripotent stem cell (iPSC) culture.
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Allogeneic cell therapies offer incredible promise, but scaling up PSC manufacturing presents unique challenges. Explore these hurdles along with solutions for consistent, high-quality production.
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Explore how innovative bioreactor technology enables consistent and efficient scale-up of human induced pluripotent stem cells (hiPSCs) from 100ml to 3L, ensuring optimal cell yield and quality.
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Explore guidance on the materials and methods recommended for assembling a perfusion system using a 60 Micron Plastic (PE) Retention Filter with a Vertical-Wheel Bioreactor.
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Vertical-wheel bioreactor technology offers a scalable, controlled environment for sensitive cell types. Discover its benefits, applications, and cGMP compatibility in this FAQ.
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Unlock the full potential of your hiPSC research. Explore how Vertical-Wheel technology enhances culture homogeneity and expansion, paving the way for breakthroughs in cell and gene therapy.
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Explore how the dynamic microenvironment of bioreactors influences the production and composition of extracellular vesicles (EVs), including exosomes, secreted by human mesenchymal stromal cells (hMSCs).
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Learn about a method for generating human iPSC-derived cerebellar organoids that allows for the reproducible and large-scale production of organoids that recapitulate key features of cerebellar development.
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Explore the use of 3D cell culture to increase the clinical production of stem cells. By culturing cells on microcarriers or as aggregates, researchers can retain typical stem cell characteristics while increasing production.
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Learn about the advantages of 3D suspension culture for iPSC expansion, including enhanced pluripotency and genetic stability. Discover how this technique yields high-quality iPSCs for regenerative cell therapies.
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Allogeneic Natural Killer (NK) cell therapy offers a promising avenue for cancer immunotherapy. However, traditional platforms struggle to achieve the scalability required for clinical translation and commercial manufacturing.
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Delve into a study that examines the possibility of the combination of NK-cell-derived EVs and CBP as a viable immunochemotherapeutic strategy for resistant cancers.
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Equine mesenchymal stromal cells (eMSCs) offer therapeutic potential for various conditions. Dive into this examination of the bioreactor culture of eCB-MSCs using microcarriers for enhanced cell yield, reproducibility, and homogeneity.
CONTACT INFORMATION
PBS Biotech, Inc.
4721 Calle Carga
Camarillo, CA 93012
UNITED STATES
Phone: +1 (805) 482-7272
Fax: +1 (805) 383-7727
FEATURED SOLUTIONS
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The PBS 0.5L Single-Use Vessel with PSC Perfusion Filter (60µm) is a compact, scalable vessel designed for optimization of PSC culture under controlled perfusion medium exchange.
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Explore a novel bioreactor design focused on gentle mixing and consistent environments. Learn how it supports homogeneous expansion and maintains cell integrity.
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This innovative bioreactor system supports scalable cell therapy manufacturing with advanced hydrodynamics and multi-cell type compatibility to ensure optimal culture environments and reliable production.
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The PBS-3 Vertical-Wheel bioreactor is designed to take your cell culture process to the next level. Process development and optimization started in PBS-Minis can be scaled up into this self-contained bioreactor with customizable control of process parameters.
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The PBS-15 Vertical-Wheel bioreactor is the next step in scaling up the cell culture process started in the PBS-Minis and PBS-3. With a maximum working volume of 15L, the PBS-15 can accommodate larger scale process development or production for clinical trials.
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The PBS-80 Vertical Wheel bioreactor is the ultimate tool for large-scale manufacturing of therapeutic cells. With the currently largest available working volume of 80L, the PBS-80 can handle commercial manufacturing of cell therapy products.
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Unleash the potential in your cell therapy with scalable, single-use bioreactors from 0.1L to 80L, empowering scientists to develop cell therapy products that combat cancer, diabetes, and heart failure.
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The PBS MINI bioreactor, with Vertical-Wheel technology, offers gentle, scalable, and reliable cell culture solutions for applications ranging from MSCs and primary cells to PSC aggregates.
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The PBS-0.5 Mini single use bioreactor is compatible with 300mL– 500mL working sample volumes and the best starting point for optimizing cell therapies by leveraging the benefits of vertical-wheel mixing that can be easily scaled up for larger sample volumes.
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The PBS-0.1 Mini single use bioreactor is compatible with 60mL-100mL working volumes and is the best starting point for optimizing cell therapies by leveraging the benefits of Vertical-Wheel mixing that can be easily scaled up for larger volumes.
POSTERS
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Take an inside look into the growth characteristics, morphology, and quality attributes of hMSCs and hiPSCs cultured in vertical-wheel bioreactors.
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Discover the key requirements for efficient and linear scale-up of shear-sensitive pluripotent stem cell and other cell therapy products using the Vertical-Wheel bioreactor family.