
ABOUT US
Biopharma Powder Handling & Liquid Single-Use Solutions
ILC Dover is a world-leader in the innovative design and production of engineered flexible containment solutions for a diverse range of regulated industries, including the biopharmaceutical market. Our biopharmaceutical products expedite the manufacturing of biologics and reduce the risk of contamination to significantly impact safety, productivity, and profitability. With beginnings in aerospace in 1947, we adapted our decades of experience engineering advanced solutions for the most technically complex and logistically intricate applications, including the space suit for NASA, to provide breakthrough solutions for powder handling, processing, containment, mixing, and liquid single-use.
Our products, including EZ BioPac®, JetVent™, and JetMixer™, each do their part to achieve our mission of protecting people and their environments from the risks of critical conditions. EZ BioPac®, our purpose-built powder containment and transfer system, enables the simple and safe production of media and buffers while reducing fill-time and cross contamination. JetVent™ provides safe, automatic, and pressurized containment for HPAPIs by controlling negative air pressure to ensure proper flow into flexible-wall isolators. JetMixer™ allows for rapid mixing of powders into liquid without shear forces exerted on the powder, among other advantages.
Our custom production equipment and manufacturing facilities, which include an ISO Class 7 Clean Room, allow our single-use products to be manufactured to the most exacting standards. At ILC Dover, we are relentlessly dedicated to providing highly competitive products, advanced technology, and responsive service, and are proud to be on the front lines of global ingenuity and business excellence.
CONTACT INFORMATION
ILC Dover
One Moonwalker Road
Frederica, DE 19946
UNITED STATES
Phone: 1-302-335-3911 ext. 1506
Contact: Sales
FEATURED ARTICLES
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Flexible film isolation systems previously tended to be a composite of stainless-steel chambers and airflow modules. Here, we investigate the development of a fully disposable aseptic isolation system.
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This white paper explores eight considerations in detail and could be helpful to EHS managers and supervisors looking to select a Powered Air-Purifying Respirator system for their particular application.
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With high potency active pharmaceutical ingredients (HPAPIs) comes a heightened awareness of this requirement and the added burden of a higher level of regulatory oversight.
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Does your powder system help to eliminate productivity bottlenecks, decrease material waste and the cost of raw materials, and simplify the changeover of the line to new products?
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Two methods of containing blenders have been demonstrated. Included here are the use of flexible enclosures and separate, disposable powder transfer systems.
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Media and buffer preparation is a key part of the biopharma manufacturing process. Improving the powder transfer process makes this step cleaner, safer, more efficient,and reduces costs.
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This clear hood for biopharmaceutical facility employees improved safety and performance while promising economic savings.
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Find a reliable source of cGMP raw materials, diverse packaging options, and solutions for material storage that can minimize the total cost of ownership and maximize productivity.
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Enhance your ADC manufacturing processes by leveraging the performances and inherent benefits of single-use isolators.
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Improve your fluid transfer by exploring customer-specified assemblies designed for the storage and transfer of sterile fluids in biopharmaceutical manufacturing with an optimized quality system.
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Technology has evolved to make high-containment systems financially reasonable. Explore how single-use containment technology impacts capital spending and operating expenses.
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In the containment world for OSD processing, we see smaller batch sizes and more changeover. Here, we consider the pros and cons between hard-wall systems and flexible-wall containment systems.
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Review a full lifecycle safety structure that ensures the highest standards of operator protection from single-use flexible film containment systems.
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This webinar covers a well-designed, single-use flexible enclosure system that delivers equivalent if not better containment performance than a hard-shell isolator, at a fraction of the cost.
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Here, we explore the advantages and disadvantages of lyophilization and share examples of lyophilizer solutions and containment designs.
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Explore applications where flexible isolators have been used, including the containment assessments to confirm performance and ergonomic benefits, and a specific case of using a negative pressure isolator.
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Understand the challenges of small molecule manufacturing and HPAPI containment as well as the benefits of using secure single-use technology to expand your capabilities and meet process demands.
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Learn about best in class solutions to streamline the transfer process, resulting in more accurate and faster production and improved batch cycle times.
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The on-demand webinar CMO/CDMO Facilities Gain Value with Single-Use Containment presents a case study for an OSD process, shared facilities and HBEL/ADE requirements.
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Powder-handling processes haven’t kept pace with advances in single-use transfer technologies. This application note posits a better way to bring powders to the hydration process for upstream manufacturing.
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Don’t risk operator exposure and potential contamination with untested or unproven single-use valve technologies.
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For operations where low shear and high product integrity are required, traditional technologies pose a risk to the quality of the final product.
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While media and buffer materials have been notorious contributors to airborne particulates and contamination in the past, they don’t have to be.
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Upgrading to modern single-use powder handling gets your product to market without time wasted on complicated weigh and dispense steps, cleaning validations, or worries about powder in the air.
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The current trend of increased potency of drug substances is driving the need for better cleaning methods to reduce cross contamination.
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Read how upgrading to modern single-use powder handling gets a product to market without time wasted on complicated weigh and dispense steps, cleaning validations or powder in the air and in the suite.
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At ILC Dover, we are always "creating what’s next" by listening carefully to our customers. In response to customer input and emerging regulations, we've developed a robust new film to support our DoverPac® Containment Solutions line. This revolutionary product, ArmorFlex® 110, delivers permanent static dissipative properties while meeting FDA and 2002/72/EC requirements for food contact.
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The Drum Transfer System (DTS) described in this article has been validated in a variety of processes requiring the contained transfer of drummed materials in pharmaceutical applications. Processing operations described here include milling, subdividing, charging, and repackaging. Submitted by ILC Dover
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Product Sheet: G2Pac™
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The DoverPac® continuous liner system provides the advantage of replacing packs without breaking containment, unlike using inflatable heads or having operators shuffle tube stock.
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The process for this application consists of the controlled feeding of a mill through a feeder. The powder is introduced into the feeder using a drum transfer system.
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The Flexible Document Transfer Enclosure is designed to allow paperwork used in pharmaceutical processing to be handled in a contained way so that powders are not transferred onto the documents and to areas or individuals that are not protected.
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White Paper: Flexible Containment Solutions Guide Mill Containment System — Underdrive Design
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The interest in the use of containment for the development and manufacture of active pharmaceutical ingredients (APIs), including sensitizers by contract manufacturers and contract research organizations, is expanding. By Alan E. George, ILC Dover
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This article provides a review of various innovative solutions, a provocative thought process for customized installations if needed, and a look at a technology verified to reduce the overall cost of ownership for contained processing. By ALAN E. GEORGE
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Given the increase in highly potent API manufacturing, the use of the Coaxial neck DoverPac® system, with either rigid isolators or flexible enclosures, is a complementary processing option. By ILC Dover
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Flexible Containment for offloading drummed materials in a safe and efficient manner is provided by the Drum Transfer System (DTS) platform. The DTS consists of an enclosure attachment frame, a support stand, a drum lifter, an enclosure, an outer drum sleeve, and discharge softgoods that are dependent upon your process equipment.
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One of the simplest, most convenient and most cost-effective ways to ship, receive, and store bulk powder ingredients, including active pharmaceutical ingredients (APIs), intermediates, excipients, and ingredients for buffers and media, is in drums. The contents of these will need to be transferred before use, and this process can be challenging. Integrated drum transfer solutions make the process simpler, cleaner, and faster, improving safety for both workers and patients, as well as protecting any remaining ingredients for storage.
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The Flexible Document Transfer Enclosure is designed to allow paperwork used in pharmaceutical processing to be handled in a contained way so that powders are not transferred onto the documents and to areas or individuals that are not protected. Submitted by ILC Dover
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Alan George is the Product Manager for ILC Dover’s flexible containment and disposable systems and has been actively supporting the development of flexible containment solutions for a wide range of processing equipment for over 13 years. In this Q&A, Alan responds to 7 questions concerning the use of flexibles to support powder charging in biopharmaceutical operations.
NEWS
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ILC Dover Secures North Carolina Facility To Expand Dry Repack Capabilities And Build Out cGMP Raw Materials Portfolio1/19/2023
ILC Dover LP, specializing in innovative single-use solutions for biotherapeutics and pharmaceutical processing, has opened a new facility in Lillington, North Carolina to offer pre-filled trusted-weight cGMP raw materials for the growing biomanufacturing market. As a solutions provider for the expanding life sciences industry, ILC Dover continues to meet market demands by developing comprehensive solutions customized to customers' unique needs and end applications.
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ILC Dover Announces New Multi-Compendial Water For Injection Solutions For Biopharma And Cell & Gene Therapy Market8/1/2022
ILC Dover, specializing in innovative single-use solutions for biotherapeutics and pharmaceutical processing, announced the launch of Water for Injection (WFI) for the biotherapeutics market.
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Solving API Manufacturing Challenges With Flexible Containment Webinar Announced for June 216/7/2022
Are you concerned about operational safety and efficiency during API manufacturing? This webinar discusses some of the common challenges faced in handling powders during HAPI/API manufacturing. Key strategies to mitigate risks associated with these issues will be shared including how flexible containment solutions can optimize powder handling during chemical synthesis.
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ILC Dover Plans To Build New Manufacturing Facility In Poland To Meet Biopharma Industry Needs5/9/2022
ILC Dover LP, specializing in innovative single-use and chemical workflow solutions for biotherapeutics and pharmaceutical processing, announced plans to break ground on a new 90,000 sq ft manufacturing site located in Gliwice, Poland in response to continued strong growth within its life sciences business. The state-of-the-art facility equipped with 20,000 sq ft of ISO Class 7 cleanroom capability will manufacture initially single-use powder bags, single-use liquid bags, and single-use fluid transfer assemblies. The new site will provide redundant supply capabilities, reduce the lead times for its European and Asian customers and manufacturing will be consistent with the Company’s global quality system.
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ILC Dover Announces Single-Use Bags Ideal For Biopharma And Cell/Gene Therapy Drug Manufacturers3/29/2022
ILC Dover LP (“ILC Dover” or the “Company”), specializing in innovative single-use solutions for biotherapeutics and pharmaceutical processing, announced its launch of liquid single-use bioprocessing bags, representing the first of many new products for handling and supply of sterile liquids for the biotherapeutics market.
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ILC Dover Announces Acquisition Of KSE Scientific To Assist Biopharma, Med Device And Cell & Gene Markets12/16/2021
ILC Dover, Inc., a leading designer and manufacturer of high-performance materials for life critical and primarily life sciences-based applications, today announced the acquisition of KSE Scientific (“KSE”), a sterile solutions manufacturer which specializes in the production of Water for Injection (WFI) and related media and buffer solutions for biopharma, cell & gene therapy, tissue banking and medical device end-markets.
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ILC Dover Announces April 13th Webinar For Recently Developed Aseptic Isolator System4/7/2021
With the development of ILC Dover’s new Aseptic Isolator system new opportunities have opened up for many organizations who were previously able to conduct fill finish activities due to facility restraints or expensive closed barrier systems.
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ILC Dover Expands Containment Technologies With Acquisition Of UK-Based Solo Containment9/9/2020
ILC Dover, Inc. (“ILC Dover” or the “Company”), a world leader in the design and production of single-use flexible solutions for pharmaceutical and biopharmaceutical manufacturing, today announced the acquisition of Solo Containment, Ltd. (“Solo”), a specialist manufacturer of flexible film isolators based in the United Kingdom. The acquisition will grow ILC Dover’s global pharmaceutical and biopharmaceutical business, expanding its solutions for high containment and powder transfer to include aseptic flexible isolators, among others.
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ILC Dover Announces September 17 Webinar Gaining Value With Single Use Containment For Contract Manufacturers9/3/2019
CMO and CDMO facilities have experienced fast paced growth and with more potent compounds planned for launch in the future the good times will continue. There are unique problems with growth for these contract facilities and many have to do with the controls required to assure proper containment of compounds in a multi-use facility. Containment is critical to assure personnel are not exposed to the affects of the drugs and to mitigate issues with cross contamination. These additional controls require greater attention to SOP’s particularly for cleaning and validation. These cleaning procedures reduce the uptime of equipment or process suites then limiting the facility to take on more campaigns and grow faster. This is where single use containment can expedite the changeover in campaigns while still providing the needed controls.
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ILC Dover Opens New Production Facility In Cork Ireland5/21/2019
MEP Deirdre Clune officially opened the new ILC Dover manufacturing facility in Blarney Business Park, Cork today (Tuesday) alongside ILC Dover CEO and President Fran DiNuzzo.
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ILC Dover To Exhibit Flexible Containment Solutions At INTERPHEX 2019 Conference3/15/2019
At ILC Dover we are focused on containing your process to get your product to market faster, safer, and cleanly.
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Protective Equipment Is Critically Important For Ebola Responders2/14/2019
The rare Ebola virus has set out on another deadly rampage. This latest outbreak in the Democratic Republic of Congo is the worst in the country’s history—more than 400 people have died from the epidemic since August. Obviously tragic for its victims, the virus threatens the healthcare providers who care for these victims as well.