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The biomanufacturing legacy of the Grifols campus in Emeryville, California, began with Chiron and Cetus in the 1980s, with innovative advancements in yeast expression, viral discovery and the development of PCR. Three decades of process development and manufacturing experience is the foundation of the business today at CHIRON® Recombinant Proteins.

CHIRON® Recombinant Proteins partners with companies interested in developing complex proteins into therapeutics, vaccines or diagnostics. Our state-of-the-art GMP biological manufacturing CMF facility located in the San Francisco Bay Area is well positioned to provide long-term, high-quality, commercial manufacturing of recombinant biologic drug substances to our customers, regardless of their global location. This location, in one of the major U.S. biotech hubs –– home to many emerging biotechnology companies lacking extensive internal development and manufacturing resources –– provides us with an opportunity to effectively serve a host of local customers.

CHIRON® Recombinant Proteins is staffed by highly experienced and talented people with diverse expertise and educational backgrounds within the field of biotechnology. Our staff welcomes the opportunity to have face-to-face visits with clients where new ideas can be discussed. With their significant tech transfer expertise and access to the state-of-the-art facilities and equipment within the CMF and new pilot plant, including R&D, process development and analytical laboratories, our scientists can rapidly identify solutions for our CDMO clients.

Grifols is a global healthcare company founded in Barcelona in 1940, committed to improving the health and well-being of people around the world. We produce essential plasma medicines for patients to treat rare, chronic and, at times, life-threatening conditions. The company provides a comprehensive portfolio of solutions in transfusion medicine and also offers hospitals, pharmacies and healthcare professionals information and services that deliver efficient, expert medical care.


The Benefits of Partnering with CHIRON®
Chiron is ready to partner with you to support development of complex proteins into new therapeutics, diagnostics and vaccines.

Chiron has development and cGMP production capacity for recombinant proteins in yeast.

cGMP production of recombinant proteins made in E. coli is performed in Chiron’s new state-of-the-art facility.

Chiron excels in expressing complex, challenging proteins that don’t fit into a predefined program. Our scientists are creative and innovative applying new techniques to solve problems of yield, protein folding, purity, and more. The best projects are those that have never been done before and have the potential to change the view of medicine or manufacturing.

Chiron has analytical method development and testing to support all stages of product development and manufacturing.

Chiron supplies recombinant Human Immunodeficiency Virus (HIV) antigens including HIV-1, HIV-2 and HIV-1 Type O from the envelope and gag regions. These antigens are currently used in immunoassays that test blood donations worldwide as well as clinical testing of patients.

Chiron supplies recombinant antigens from the Core, NS3, NS4 and NS5 regions of the Hepatitis C Virus (HCV) genome. These antigens are currently used in immunoassays that test >60% of the blood donations worldwide as well as clinical testing of patients.

Chiron supplies recombinant Hepatitis B Virus (HBV) core antigen for immunoassay diagnostics. This antigen is used in immunoassays that test blood donations worldwide as well as clinical testing of patients.

Our HBV antigen is a licensed biologic with the FDA.