FEATURED ARTICLES

• Cell Food: How Smart Media Formulations Drive Cell Culture Performance

  Efficient drug production through cell culture depends on the complex interplay between the drug molecule, the cell, and the process. How can you balance cell growth and productivity?

• Seizing Opportunity: Disruptive Forces In Advanced Cell Culture Tech

  The market for biological drugs continues to grow at an impressive pace over the past years. Explore three key trends that will underpin the sustainable growth of biopharma beyond COVID-19.

• Developing Life-Saving Medicines Through Cell Culture Technologies

  Evonik Health Care's Dr. Martin Schilling and Johns Hopkins University Professor Michael Betenbaugh discuss advances and trends in cell culture-based production of biological drugs.

• How mRNA Technology Is Shaping The Future Of Medicine

  Discover how mRNA technologies open the doors to a whole range of new gene therapies and the role of lipid nanoparticles (LNPs) in current and future developments.

• Exclusive Synthesis - API, HPAPI, And Intermediates

  Evonik is one of the world's top 3 CMOs for API and intermediates. The brochure offers insight into their capabilities and the technologies they use to address the specific needs of the largest and most complex synthesis problems life science companies face today. 

• LNPs vs. Conventional Liposomes: A Short Review Of Core Structural And Manufacturing Differences

  Key differences exist between liposomes and lipid nanoparticles (LNPs), not only in their target applications, but with their actual morphology, composition, and manufacturing process.

• Highly Pure L-Carnosine For Cell Therapy Media Applications

  Cell therapies based on MSCs and T-cells have enabled a series of breakthroughs in patient care. Cell-based, engineered tissues are making significant contributions in the field of regenerative medicine.

• Post COVID-19: Pharma Supply Chain Shifts To A Regional Model

  The pandemic has highlighted vulnerabilities in the global supply chain. To reduce risk, initial steps are being taken to review how to increase local production capacities and tighten potential supply chain gaps.

• Reducing The Surface Friction Of Medical Devices - A New Functional Application For A Commercial Biomaterials Surface Modification Technology

  Devices such as introducer sheaths, delivery catheters, endoscopes, and neurovascular microcatheters aim to minimize trauma during insertion and removal, reduce tissue inflammation, enable maneuverability through tortuous blood vessels, and improve patient comfort. Surface properties should promote smooth movement between certain device components.

• Polymeric Implants, Formulations For Intravitreal Administration

  Polymeric formulations such as intra-ocular implants designed for the precise intravitreal delivery of drug products represent one of the most promising, yet challenging, areas of pharmaceutical focus.

• Cell Culture Media Dipeptides For Biopharma Process Improvement

  With the right selection of dipeptides, keto acids, special amino acids or other derivatives at hand, biopharma companies can realize substantial process improvements.

• Lipid Nanoparticle Delivery Tech: Beyond mRNA Vaccines

  What applications are being explored for lipid nanoparticle delivery technologies? Dr. Jay Natarajan, Director of R&D, competence center for LNP technology, answers questions here.

• Formulation, Manufacturing Capabilities For Cell & Gene Therapies

  The engagement of a CDMO partner with a broad portfolio of cell and gene therapy delivery technologies, a strong formulation track record and manufacturing flexibility is the preferred pathway for success.

• L-Glutamine Dipeptide To Improve Cell Culture Performance

  Depending on the cell line, clone, product and media formulation used for biopharmaceutical production, it can be helpful to evaluate additional glutamine dipeptides to maximize performance. 

• Bioresorbable Copolymer Advances In Wound Healing, Pediatric Devices

  Isabel Wahl, Head of Evonik’s RESOMER development lab, discusses a new bioresorbable copolymer combining mechanical strength with rapid degradation for wound healing and pediatric devices.

• Outsourcing Microbial Fermentation To A CMO: Key Considerations

  Advances in synthetic biology and genetic engineering have fueled the potential of fermentation-based manufacturing. Here we examine key trends and  challenges to the approach.

• High Purity Of Amino Acids: Foundation Of Reliable Media Performance

  Amino acids used in biopharma processes must be animal-origin free, governed by strict change control policies and utilize precise processes to eliminate endotoxins and heavy metals.

• Developing The Highest Purity PEGs, mPEGs

  Few suppliers of standard or custom PEGs and mPEGs have the necessary competencies to address quality and purity requirements or to overcome technical manufacturing challenges.

• Boost Cys-Solubility, Performance In Cell Culture Media Apps

  While the solubility of free L-Cysteine is high at neutral pH, the applicable concentration in basal and feed media is limited. Read more about an available solution for solubility and performance challenges.

• Enhancing Stability, Survival & Performance Of Microbiome-Based Products

  For pharma and biotech companies focused on the development of microbiome products, it's important to develop oral dosage forms that can deliver specific formulation or application outcomes. 

• Recombinant Collagen Made Via Fermentation Can Address Key Unmet Market Needs For Safety, Sustainability And Acceptability

  The production of recombinant collagen made via fermentation-based processes addresses market needs for collagen that is safe, sustainable, reproducible, and acceptable to consumers. 

• Enhancing The Solubility Of L-Tyrosine In Cell Culture Media Applications

  Because L-Tyrosine is an important amino acid for protein synthesis and cellular metabolism, finding a solution to its solubility challenge can be critical to maximize process performance. 

• Emerging Trends, CMO Solutions For Protein Fermentation

  To meet growing market demand for the use of protein-based products that have a sustainable ecological footprint, substantial efforts are now underway to utilize microbial fermentation-based processes.

• Cell Culture Media Ingredients: Optimized Stability And Solubility

  Cell culture media used in biopharma production have come a long way in recent decades. This interview discusses key solubility, stability and other challenges that many biopharma companies still face.

• Lipid Nanoparticles Are Having A Breakout Moment

  After more than 25 years of commercial use with almost 20 parenteral drug products, lipid nanoparticles (LNPs) are having a breakout moment. While LNPs are now a proven drug delivery technology to penetrate target cells and ensure release for reliable systematic or local delivery, their true market potential as a gene and cell therapy enabler has only become clear to many since COVID-19.

• A New Aseptic Solution For The Filling Of Complex Parenterals In Powder, Liquid Or Suspension Form

  Traditional filling lines lack the necessary versatility to address the growing number of complex and personalized parenteral drug products that are now being brought to market. Evonik has recently qualified a new modular aseptic filling platform that will efficiently fill drug products in powder, liquid, suspension or combination form.

• Optimize Development And Upscale Of API/HPAPI And Fermentation Projects

  Discover some of the key expectations of customers who are reviewing CMOs to support the development and upscaling of their next major project.