Visualization, Automation Enhance Efficiency Of Thermo's Galileo LIMS for ADME/TOX Experiments

Philadelphia, PA - Thermo Electron Corporation announces the availability of Galileo LIMS v 3.1, providing additional functionality to increase efficiency in the demanding high-throughput environment of in vitro ADME/Tox discovery laboratories.

Highlights of the latest release of this unique laboratory information management system (LIMS) include:

• automatic results flagging, using a three-color system to indicate acceptance, rejection or flagging of results;
  
• rapid study entry to accelerate the entry of concentration or raw data from analytical instrument into the LIMS;
  
• the addition of "IC50 shift" – a new experiment type to elucidate enzyme inactivation;
  
• and support for PAMPA permeability studies that are important in early screening of compounds.

In addition, Galileo now interfaces with more analytical instruments, including a bi-directional digital interface to Xcalibur v 1.4 and 2.0, the controlling software for Thermo's line of mass spectrometers.

"Galileo was designed to eliminate the tradeoff between rigorous results at reduced throughputs or increased capacity via standardization on a single workflow," said Joel Usansky, Ph.D., Galileo product manager. "The latest version of Galileo provides the necessary functionality to increase each user's productivity while remaining flexible for the early discovery environment. In Galileo, they will find calculations for standard ADME experiments, templates and charting galleries that visually display results for rapid data review and decision-making. This LIMS eliminates the need to transfer data to multiple external applications such as spreadsheet, graphical and curve-fitting software."

Introduced in mid-2003, Galileo is a fully integrated system that allows users to plan, design, calculate, graph and report in vitro ADME/Tox data in a single application. The experimental procedure and definition of samples, creation of analytical run worklists, interfacing to analytical instruments such as LC-MS and plate readers, creation of calibration curves, and calculation of final results can be performed by Galileo and saved to the Oracle database.

Many features make the Galileo solution easy to use: multi-site scalability, integrated scheduling capabilities, adaptable data reduction and analysis, powerful curve fitting and graphing, creation of result tables, and document management.

SOURCE: Thermo Electron Corporation