Viresolve® Pro Solution: Prefilter Selection Guide

Viral filtration is a crucial safety step in biologics production, but residual protein aggregates and process impurities can severely limit filter capacity, driving up manufacturing costs and increasing filter area requirements. Integrating the correct prefilter is the proven method to mitigate these challenges, enhance process economics, and ensure run-to-run consistency. Effective prefilter selection is not one-size-fits-all; it must be driven by the specific characteristics of your feed stream. For challenging monoclonal antibody (mAb) streams, adsorptive or charge-based binding chemistries are generally more effective than simple size-exclusion for removing plugging aggregates. Data confirms that capacity improvement relies heavily on matching the prefilter's operating window, including optimal pH and conductivity, to your precise process conditions.

Access the full brochure for a comprehensive overview of key criteria and a quick-selector table that maps filter properties, optimal feed conditions, and hardware compatibility to help you maximize viral filter capacity in your process.