VEGF Signaling Pathway

Vascular Endothelial Growth Factor (VEGF) signaling is crucial for the normal development and maintenance of blood vessels. Under healthy conditions, VEGF ensures proper vascular function and homeostasis. However, in pathological states, elevated levels of VEGF can lead to the formation of abnormal blood vessels through the process of angiogenesis. In addition to its role in vascular development, VEGF is also involved in neurodegenerative processes and may offer neuroprotective benefits in Alzheimer's disease (AD). Research has shown that VEGF expression is significantly reduced in individuals with AD, as evidenced by lower levels in patients' serum and in the cerebral capillaries of post-mortem brain tissue.

Experimental treatments with VEGF in APP transgenic mice have demonstrated a reduction in memory impairment and beta-amyloid deposition. Learn more information on VEGF's role in other diseases and its therapeutic potential.