Newsletter | July 28, 2025

07.28.25 -- Using Algae To Manufacture Oral Biologics With Lumen Bioscience's Craig Behnke, Ph.D.

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Webinar: Process Intensification Strategies: Your Guide to "Doing More with Less"

Unlock the full potential of process intensification in biomanufacturing with Cytiva’s expert-led webinar. Discover how to overcome scale-up challenges and regulatory hurdles while maximizing efficiency, quality, and speed—especially during the critical Phase 2 to commercial transition. Learn cutting-edge strategies like high-seed fed-batch and continuous capture. Don’t miss this chance to future-proof your manufacturing process. Register now! Click here to learn more.

FOCUS ON UPSTREAM MANUFACTURING

Using Algae To Manufacture Oral Biologics With Lumen Bioscience's Craig Behnke, Ph.D.

Lumen Bioscience is putting the farm in biopharma — literally! In this episode of Better Biopharma, Lumen's EVP of production and development, Craig Behnke, Ph.D., explains the company's chlorophyll-powered approach to bioprocessing using photosynthetic cyanobacteria.

 

 

CD8+ Single Positive T Cell Differentiation From HiPSC: A Feeder-Free Method

Learn about a feeder-free method to differentiate CD8+ single positive T cells from human induced pluripotent stem cells, which offers promising advancements for scalable and efficient cell therapies.

 

In Vitro Glycoengineering (IVGE): Taking Control Of Glycosylation

Discover how to gain precise control over one of the most common and critical forms of protein modification for therapeutic benefit and stability.

 

Drug Discovery And Screening, A Digital Era For RNA-LNP Therapeutics

Learn about the key stages of drug discovery and screening as well as how to overcome bottlenecks in screening mRNA-LNPs to rapidly develop genomic medicines.

 

MAPK Signaling Pathway

Mitogen-activated protein kinase cascades regulate key cellular processes like proliferation, differentiation, and apoptosis. Explore how these pathways maintain cellular homeostasis and contribute to disease development.

 

Advanced Technology Platform For Stem Cell-Derived Exosomes

The demand for extracellular vesicles (EVs) is increasing due to their therapeutic promise. Explore two scalable platforms that address production challenges to support EVs' expanding applications.

 

Optimizing Biotherapeutic Protein Expression With CHO Vector Technology

Review the development of a high-strength synthetic gene promoter that enhances titers while maintaining exceptional product quality and expression stability.

 

Engineering CHO K1 Cells With Three Orthogonal Transposase Systems

Transposase-mediated genome engineering enables the robust and stable relocation of discrete DNA segments (transposons) in the genome, providing a valuable tool for stable transgene expression.

 

Rapid Discovery Of CD200R1 Antagonist VHHs Via Single B Cell Technology

Here, we used single B cell antibody discovery to rapidly identify a diverse set of high-affinity, neutralizing VHH from immunized llamas against CD200R1, an emerging therapeutic immune checkpoint target.

 

CHO Culture: Bioprocess Modes Batch Fed-Batch and Perfusion

Explore the differences between three cell culture bioprocesses using bench-scale CHO cells, and why tracking specific parameters is important to achieving the inoculation of bioreactors at high viability.

 

Achieving Rapid, High-Titer Expression For Next-Generation Biologics

This advanced cell line development technology overcomes production challenges related to the expression and scalability of complex biologics.

 

Next-Generation Cell Therapy: Eliminating Thermal Shock In Electroporation

Conventional electroporation methods struggle with damaging heat buildup. Discover how innovative flow technology leverages physics to protect cells and enable large-scale therapeutic production.

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Webinar: Efficient Scale-Up of Monoclonal Antibody Production: From Bench Top to 500L

Join Thermo Fisher Scientific for a live webinar on scaling Herceptin production in CHO-K1 cells from 3L to 500L using HyPerforma™ and DynaDrive™ bioreactors with Gibco™ Efficient-Pro™ media. Discover how consistent productivity and product quality were maintained across scales, supported by a streamlined downstream process. Gain valuable insights into efficient, scalable monoclonal antibody (mAb) production. Click here to learn more.

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