UNOsphere™ Q Anion Exchange Support
Be Productive!
In the bioprocess industry, the isolation of biomolecules from crude feedstock is one of the most demanding chromatographic steps in the downstream process. Biopharmaceutical manufacturers are under increasing economic pressure to reduce drug production costs. These factors require that the media used in the capture step have very high binding capacities at fast linear velocities while maintaining low column backpressure.
UNOsphere is a new-generation polymeric support, produced in a single-step polymerization process, that delivers high productivity in the capture step.
The single-step polymerization produces a support unsurpassed in quality and batch-to-batch reproducibility. Features of UNOsphere Q and S ion exchange media include:
- Optimized to operate under 2 bar backpressure at linear velocities of 1,200 cm/hr
- Stable to 1 M NaOH exposure up to 10,000 hours
- Efficient capture of biopharmaceutical molecules from crude feedstreams
- Large pores that result in ultrahigh binding capacities at fast linear velocities
- Hydrophilic polymeric beads engineered for high mechanical stability and low backpressures
- Robust polymer designed to withstand repeated clean-in-place cycles
- Availability in biopharmaceutical manufacturing quantities
- Fully supported for regulatory submissions
•Bulletin: UNOsphere™ Q Anion Exchange Support
•Bulletin: UNOsphere™ Q Support Technical Data
Binding and backpressure properties of UNOsphere media.
Column size, 1.1 x 20 cm.
Upper panel, UNOsphere S media loaded with 2mg/ml human IgG; buffer, 50 mM sodium acetate, pH 5.0.
Lower panel, UNOsphere Q media loaded with 5 mg/ml BSA in 10mM Tris, pH 8.5.
Backpressure (—); 10% breakthrough capacity (—).