Turnkey Solutions To Improve Cell Culture Performance

By Janice Tan, PhD, Head of Upstream MSAT, Asia Pacific excluding China

Optimizing media formulations and cell culture processes are essential for efficient and cost-effective upstream workflows. A wide variety of strategies can be applied during this phase of development to improve process economics, accelerate time to market, reduce regulatory and risk considerations, and ensure business continuity. This whitepaper describes two turnkey upstream solutions that can be applied to improve the performance of monoclonal antibody (mAb) production clones and set the stage for a successful manufacturing process. A scalable, simplified feed optimization process can be used to achieve high product titers, while incorporation of chemically defined supplements can mitigate risk and facilitate favorable product quality attributes.