Tritium Labeling Service
ARC routinely offers a variety of tritium labeling services. Our basic tritium labeling service includes removal of catalyst and labile tritium. Purification will be done at extra cost which will depend on the purification method required. The following listing details the most commonly used tritium labeling services:
Catalytic Reduction with Tritium Gas
This procedure normally yields high specific activity products and requires halogenated or unsaturated precursors.
Reduction with Sodium Borohydride [ 3 H]
This procedure is rather inexpensive and requires precursors containing reducible functional groups such as aldehydes, ketones, lactones, esters, etc.
Reduction with Lithium Aluminum Hydride [ 3 H ]
This procedure offers products at almost theoretical specific activities. It also requires precursors containing reducible functional groups such as aldehydes, ketones, lactones, esters, etc.
Tritium Gas Exposure Labeling Service
This procedure involves exposing precursors containing exchangeable protons to tritium gas in the presence of a suitable catalyst.
Tritiated Water Exchange Labeling Service
In this procedure the precursor is heated in the presence of tritiated water and a suitable catalyst. This procedure offers low specific activity products.
N-Methylation using Methyl Iodide [ 3 H]
This procedure is usually employed to prepare O-methyl or N-methyl ( 3 H) products by treating appropriate precursors with high specific activity methyl iodide ( 3 H). It yields products at high specific activity, usually 80-87 Ci/mmol.
N-Acetylation using N-acetoxyphthalimide [acetoxy- 3 H]
This is a new high specific activity tri- tioacetylating reagent which can be used to prepare N-acetyl [ 3 H] products at almost theoretical specific activity.
American Radiolabeled Chemicals Inc., 11624 Bowling Green Dr., Saint Louis, MO 63146. Tel: 314-9914545; Fax: 314-991-4692.