The Levers And Tradeoffs That Drive Process Productivity

This virtual panel discussion featured David Scherr, Ph.D., a senior scientist in bioprocessing technologies and engineering at AstraZeneca, and Vadim Klyushnichenko, Ph.D., VP biopharmaceutical development and quality at Calibr-Skaggs Institute for Innovative Medicines. Scherr and Klyushnichenko discussed where productivity gains can be achieved and how development teams can improve process performance by simplifying purification strategies and reducing chromatography steps. They also explored how less-obvious constraints (e.g., developability and facility fit) shape productivity early on, as well as how complex molecules like bispecifics are redefining what process efficiency looks like.