04.27.26 -- The Importance Of Upstream–Downstream Coordination

Scaling up life-saving gene-edited cell therapies means tackling production inefficiencies. Overcoming the time-consuming and risky cell washing step is crucial for clinical and commercial success.

See how researchers demonstrated scalable hADSC expansion in stirred-tank bioreactors using microcarriers, achieving metabolic stability and consistent growth for cell therapy applications.

Selecting and engineering the right cell line is not simply a technical milestone; it is a strategic decision that shapes cost of goods, development timelines, and the overall probability of success.

Achieve scalable MSC manufacturing by implementing closed systems and modular scale-out strategies that minimize contamination risks and ensure consistent cellular stability and efficacy.

Leverage process analytical technologies (PAT) to gain real-time insight into product quality, strengthen control strategies, and build more efficient, scalable manufacturing processes for future success.

Glycoprotein therapies face variable glycan profiles. An alternative approach, IVGE, moves modification outside the cell for true molecular control, ensuring consistency and speed.

Learn about a high-throughput screening method that successfully optimized cell culture media, leading to a greater than 3-fold improvement in viral genome titer for AAV2 production.