The Downstream Process: Playing A Crucial Role In Extracting Essence

Development of an efficient downstream process (DSP) is crucial for the successful production of bispecific antibodies (BsAbs). In the following study, Mycenax highlights the challenges associated with BsAb purification due to their complex structure and the presence of product-related impurities. A comprehensive DSP strategy involving chromatography techniques such as ion exchange, hydrophobic interaction, and mixed-mode chromatography was employed. By optimizing purification steps and introducing specific additives, significant improvements in product yield, purity, and removal of impurities were achieved. This work demonstrates the importance of a tailored DSP approach in overcoming the challenges of BsAb purification and ensuring the production of high-quality drug substance. Download the full article to learn more.
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