The Cost Of Failing To Protect Your Final Biopharmaceutical Product

By Graeme Proctor

During downstream processing, the value of a product increases with every unit step of the operation, designed to both remove impurities and concentrate the biologically active component.

Each of these unit operations involves a significant cost to the biopharmaceutical manufacturer. From cell harvesting and clarification, through affinity chromatography, buffer exchange, cation exchange chromatography, viral reduction, anion exchange chromatography, viral inactivation, concentration, sterile filtration and filling, value is added and is incremental.

Cost breakdown