The BioContinuum™ Seed Train Platform

The seed train is a critical part of the bioprocess, generating sufficient biomass to inoculate the production bioreactor and begin protein production in an optimized manner. In a traditional seed train, this is achieved by passaging cells from a working cell bank vial through increasingly larger cultivation systems including shake flasks, rocking motion bioreactors, and stirred tank bioreactors.

The typical seed train process is time- and labor intensive, requiring operators to transfer and cultivate the cells manually. It also has an increased risk of contamination due to the open nature of the early stages of cell expansion, when cryovials are thawed and cells are manually transferred under a laminar-flow hood.

The BioContinuum™ Seed Train Platform provides an integrated and versatile solution to unleash the potential of perfusion, making the seed train faster, safer, and offering an unprecedented advantage for biomanufacturing. Each component of the platform is agnostic of the manufacturing template already in place and can be integrated into a fully compatible solution or used in a standalone approach. Using these technologies, we have developed workflows that can be transferred to accelerate process development and technical transfer.