08.22.25 -- STREAM Edition: Developing An In Vivo CAR-T Cell Therapy

Tom Wells, Director of Life Sciences at 4C Associates, explains that the basic principles of procurement are consistent across industries, but success in life sciences demands a deep understanding of the scientific and business objectives to truly identify and create value.

Experts take you through the entire selection process for primary packaging components for lyophilization and provide aspects to consider for all relevant attributes.

The market for mAbs and mAb variants is growing rapidly. Explore the latest strategies and advancements in early stage mAb up- and downstream process development.

 On this episode of Better Biopharma, Interius BioTherapeutics’ Sianny Christanti and Babu Medi, Ph.D., explain how the company is re-engineering a lentiviral vector to enable INT2104, its off-the-shelf, in vivo CAR T-cell therapy. They discuss the vector's design and its manufacturability, as well as the analytical and regulatory challenges of bringing this first-in-human therapy to the clinic.

Gain insights into the nuances of cleanroom conceptual design for GMP operations and learn how an integrated approach can ensure regulatory compliance, functionality, and environmental performance.

Endotoxins can cause major upheaval in downstream purification. Explore case studies using various resins that have been successfully used for endotoxin removal.