Spray Drying Strategies: Development To Commercialization

By Sandeep Kumar, R&D Project Manager/Technical Project Lead, and Billy Edwards, Biosciences Account Manager, Thermo Fisher Scientific

One of the many challenges in the pharmaceutical industry today is poor oral bioavailability of drug substances due to low aqueous solubility. It is currently estimated that more than 40% of approved drugs and 70% to 90% of those dosed in clinical trials are poorly water soluble.¹ It is critical to identify effective strategies for improving bioavailability of these types of drug substances.

One such strategy is to create an amorphous solid dispersion (ASD), which improves bioavailability by increasing both the rate and extent of dissolution.² While several manufacturing techniques exist to manufacture ASDs, spray drying has rapidly become the process most widely favored due to ease of development and scalability. Thermo Fisher Scientific has established a wide range of spray drying capabilities and longstanding expertise across all scales. The case studies presented in this paper highlight our team’s spray drying experience and our dedication to helping you overcome obstacles that could slow your path to market.