Seasoned scientists and team leaders at Cytiva present the latest trends in cell culture technology as well as strategies to accelerate cell line development, media development, and raw material characterization. Additionally, they discuss tools and enablers for scale-up and explore reasons to outsource process liquids and buffers. Click to watch the webinar.
When evaluating media with the goal of increasing titers, you need to ensure that protein quality is not negatively impacted. How can you reliably perform this process improvement? Use a Design of Experiment (DoE) and empirical approach. Read an example of how.
This application note demonstrates the development of a fed-batch process using ActiPro™ cell culture production medium and Cell Boost™ supplements for a CHO cell line producing a mAb. The results emphasize the importance of optimizing the feeding regimen for different cell lines.
How can you intensify your fed-batch process through reduced production duration without affecting the growth or titer profile? In this study, we replaced the conventional N-1 seed train step with high-density perfusion. This enabled 10-fold higher seed density in the production bioreactor.
When generating a cell line development (CLD) platform, one major challenge is establishing a host cell line that has the desired growth characteristics and can readily transition between cloning and production media. Here, we present a host cell line that meets these criteria and how we confirmed cell performance.
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