Single-Pass Tangential Flow Filtration, A Versatile Application To Streamline Biomanufacturing

As biopharmaceutical manufacturers seek to streamline operations and reduce costs, single-pass tangential flow filtration (TFF) is emerging as a key enabler of high-capacity, space-efficient processing. Unlike traditional TFF systems, single-pass TFF allows feed solutions to flow through a series of filters just once, minimizing shear stress and reducing hold-up volumes. This simplified flow path not only conserves valuable floor space but also enhances plant productivity without compromising product quality. Its versatility makes it suitable for purifying monoclonal antibodies, therapeutic proteins, and vaccines across various downstream steps. For facilities aiming to modernize their filtration strategies while maintaining rigorous performance standards, single-pass TFF offers a compelling solution.

Explore how this approach is reshaping downstream processing in today’s evolving biomanufacturing landscape.