Selected Drug Product Publications

Drug product development continues to evolve as biologics become more complex, delivery expectations rise, and patient‑centric formats such as prefilled syringes and autoinjectors become standard. This technical brief brings together recent peer‑reviewed publications that illustrate emerging best practices across formulation, device integration, analytical innovation, and manufacturing performance. Topics span modeling injection force for high‑viscosity formulations, optimizing prefilled‑syringe usability, and using low‑field NMR as a rapid tool for detecting aggregation.

Additional studies highlight strategies for enabling high‑dose subcutaneous delivery, improving co‑formulated biologics, and managing the unique challenges of lyophilized products — from reducing reconstitution time to optimizing single‑step drying approaches. Insights into excipient behavior, particularly polysorbate 80 stability under stress conditions, offer practical guidance for mitigating degradation pathways.

Manufacturing‑focused research examines fill–finish accuracy, filtration performance, infusion filter adsorption, and pH shifts during transport — providing data‑driven methods to reduce variability and strengthen process robustness.

Together, these publications provide a concise view of where drug product science is moving and how developers can apply these findings to improve stability, manufacturability, and patient experience.