Scaling ADC Manufacturing Without Compromising Quality

Clinical-scale ADC processes rarely carry over cleanly. Changes in mixing and solvent distribution can shift conjugation consistency and critical quality attributes, and the hydrophobicity of many ADCs tends to create bottlenecks at concentration and diafiltration. Take a look at three ways to manage that risk: CFD modeling to characterize mixing, temperature, solvent distribution, and addition effects during conjugation; membrane utilization strategies aimed at hydrophobicity-related TFF challenges; and batch genealogy paired with continuous process analytics in SIMCA®-online to support multivariate process control.

Watch to see how these approaches fit together.