Large-scale downstream processing of viruses can face a range of obstacles different from those of many biotherapeutics. These challenges mostly arise from the size and complexity of the virus, which can affect product purity and recovery. Improvements of purification tools are necessary to overcome these challenges and must be engineered for easy scalability to meet manufacturing demands. This 15-minute webcast discusses the difficulties when developing purification strategies for vaccine production and gene therapy. We will explore innovative resin designs and functionalities and examine recent case studies and current processes that benefit from these resins and purification strategies.