SaniSure Clamp Pre And Post Gamma Extended Leak Tightness Study

In single-use bioprocessing systems, connection integrity must be maintained not only during operation but also throughout storage, transportation, sterilization, and preparation for use. A common challenge with traditional hinged sanitary clamps is their tendency to create uneven compression across ferrules and gaskets, which can lead to deformation, loosening over time, and the need for manual re-tightening before deployment.

Extended leak-tightness testing evaluated clamp performance under prolonged pressure exposure in both pre-irradiated and gamma-irradiated conditions. Test assemblies incorporating a range of fittings and gasket materials were subjected to repeated pressure testing over several weeks to assess long-term sealing reliability. The results demonstrated consistent leak-tight performance without signs of loosening or the need for clamp adjustment, including components exposed to multiple gamma irradiation cycles.

For manufacturers and end users seeking dependable single-use connections, these findings offer insight into how clamp design can influence long-term sealing performance, reduce maintenance requirements, and support process readiness when assemblies are stored in advance of use.