Robust And Cost-Effective mRNA Capping: Critical Quality Attributes And Manufacturing Strategies

The capping process serves as a pivotal checkpoint for ensuring mRNA stability and translational efficiency. Achieving a robust 5' cap structure at the liter scale requires distinct strategies compared to smaller milliliter batches.

This session breaks down the industrial realities of scaling up, examining how innovative manufacturing approaches and high-performance materials such as GMP-grade vaccinia capping enzymes address cost and quality control. Manufacturers must carefully evaluate compatibility and performance when adopting these new technologies.

Watch the full presentation to refine your capping strategies and ensure process integrity for the next generation of RNA medicine.