Case Study

Re-Imagining Chromatography: Building Efficient, Connected Downstream Processes

Source: Sartorius

By Priyanka Gupta, Katy McLaughlin, Ganesh Kumar, and Sanket Jadhav

Chromatography Lab GettyImages-482759508

Process intensification strategies represent an excellent opportunity for improving overall efficiency within the biopharmaceutical industry. Significant progress toward process intensification has been made for well-established modalities such as monoclonal antibodies (mAbs), fusion proteins, and bi- and multi-specifics. The industry is also beginning to explore process intensification in newer modalities such as adeno-associated viruses (AAVs).

Most of these advances and process adaptations have been applied upstream, where the industry has many options for adopting intensification, from simple (N-1) perfusion to a steady-state perfusion process in the production (N) bioreactor. However, downstream processes have not kept up with these advances, so while upstream process intensification strategies have greatly improved productivity, the industry faces bottlenecks when purifying the feeds with increased titers.

Performing multiple downstream steps in parallel and in a connected process is a powerful approach to intensify existing and new platforms irrespective of the intensification status and readiness of the upstream process.

The case study shows a stepwise approach for integrating process intensification principles into an existing process to increase productivity, reduce costs, and improve process sustainability. The insights derived from this case study offer a tangible example of the application of process intensification principles in a downstream process.

access the Case Study!

Get unlimited access to:

Trend and Thought Leadership Articles
Case Studies & White Papers
Extensive Product Database
Members-Only Premium Content
Welcome Back! Please Log In to Continue. X

Enter your credentials below to log in. Not yet a member of Bioprocess Online? Subscribe today.

Subscribe to Bioprocess Online X

Please enter your email address and create a password to access the full content, Or log in to your account to continue.


Subscribe to Bioprocess Online