Application Note

Quantification Of Exenatide Using Xevo TQD

By Joanne Mather, Erin E. Chambers, Robert S. Plumb, and Debadeep Bhattacharya, Waters Corporation

This application note highlights the powerful capabilities of the Xevo TQD Mass Spectrometer in combination with the ACQUITY UPLC H-Class System, advanced sample preparation techniques, and optimized column chemistries to develop a highly sensitive and reliable LC-MS/MS method for the detection and quantification of exenatide in plasma. By integrating these technologies, the method achieves exceptional sensitivity, precision, and reproducibility—critical factors for accurate bioanalytical measurements in complex biological matrices. This comprehensive approach not only enhances analytical performance but also supports robust pharmacokinetic and clinical research workflows.

To explore how this method can elevate your laboratory’s analytical capabilities, discover the difference precision-engineered LC-MS/MS solutions can make.

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