Protein Manufacturing Utilizing A Titerless Baculovirus Platform

Protein manufacturing is undergoing a transformative shift with the innovative Titerless Baculovirus Platform, which leverages the well-established Baculovirus Expression Vector System (BEVS). This platform utilizes the Bac-to-Bac baculovirus system combined with suspension culture-based virus generation and long-term virus storage in Baculovirus-Infected Insect Cell (BIIC) Research Cell Banks, ensuring potency is maintained for over a decade. 

One of the platform’s groundbreaking features is Infection Kinetics Monitoring (IKM). This titerless technology eliminates the need for traditional plaque assays by continuously monitoring cell culture dynamics using advanced automated analyzers. This approach enables precise optimization of harvest timing, enhancing the scalability and reproducibility of protein yield and quality, from small-scale experiments to whole production batches. The result is accelerated manufacturing timelines by several weeks, consistent lot-to-lot protein quality, and seamless scale-up from flasks to large-scale Wavebag production. Discover how Curia’s BEVS platform can elevate your protein production processes.