Process Transfer Of CHO Cultivations Using The Minifors 2 As An Example

The scale-up of cell cultivations is frequently challenging, since process parameters cannot be adopted on a one-to-one basis. Initially, the systematic characterization of the bench-top bioreactor Minifors 2 is shown in this application note. Then a scale-up from the shake flasks to the Minifors 2 takes place, as well as a process transfer between the Multifors 2, Labfors 5 and Minifors 2, as an example.

Explore the results of process-engineering characterization that demonstrate why the Minifors 2 is recommended for CHO cell culture processes and other shear-sensitive cell types.