Principles And Practice Using SEC For Reliable Biotherapeutic Peptides Analyses

Biotherapeutic peptides, such as insulin and GLP-1 receptor agonists, present significant analytical challenges when it comes to separation using Size-Exclusion Chromatography (SEC). Their complex structures and sensitivity to environmental conditions make consistent and accurate measurement difficult, especially across different liquid chromatography (LC) platforms. Waters has addressed this challenge with its innovative ACQUITY and XBridge SEC 125Å and 250Å Columns, now enhanced with MaxPeak™ Premier technology. 

The benefits of this advanced column technology are substantial. Analysts can achieve greater confidence in measuring Critical Quality Attributes (CQAs), which are essential for assessing the safety, efficacy, and overall quality of biotherapeutic peptide drugs.

If you're working with biotherapeutic peptides and seeking a more dependable SEC solution, explore how Waters' MaxPeak™ Premier technology can elevate your analytical capabilities.