Precision Polymorph Screening With Electron Diffraction

Polymorph screening is central to understanding how a drug substance behaves in the solid state, as different crystalline forms can alter solubility, stability, bioavailability, and processing behavior. Even with broad experimental screening, minor or overlapping solid forms can remain undetected, creating hidden risk later in development or manufacturing. Electron diffraction addresses this challenge by enabling direct analysis of individual micro‑ and nanocrystals within complex mixtures, including phases present at very low levels. By resolving and identifying these minor forms, solid‑state characterization becomes more complete and quantitative. This enhanced visibility supports better control of solid‑form composition, more accurate stability assessments, and stronger quality oversight. Integrating electron diffraction into polymorph screening workflows strengthens confidence that all relevant forms have been identified and understood, reducing the likelihood of unexpected solid‑state changes as development progresses. For teams managing highly polymorphic compounds, this approach provides a clearer, more defensible foundation for solid‑form selection and control.