Precision In Nanoparticle Processing And Monodispersed Lipid Nanoparticles For Advanced Therapeutics

The biopharmaceutical industry increasingly relies on nanoparticles for targeted drug delivery, gene therapy, and vaccine development. Critical to clinical efficacy and regulatory compliance is ensuring the reproducibility, uniformity, and scalability of nanoparticle production.

This article introduces an advanced platform that addresses these challenges by enabling the precise processing and monodisperse formulation of diverse nanocarriers, including lipid nanoparticles (LNPs), liposomes, and polymeric nanocarriers. The technology uses continuous upstream and downstream operations, like single-pass tangential flow filtration (spTFF), to tightly control critical parameters such as particle size, concentration, and encapsulation efficiency. This approach results in highly uniform, monodispersed particles, which are essential for predictable biodistribution, stability, and in vivo performance, especially for RNA therapeutics.

Learn how this level of control supports highly monodispersed formulations across different nanoparticle classes and accelerates development from lab-scale to GMP production. Read the full article to explore the advantages of continuous, high-precision nanoparticle processing.