Polyclonal (Rabbit) Anti-Esx

The Ets multigene family of transcriptional regulators share a conserved, 85 amino acid 'ETS' DNA-binding domain sequence and includes several known oncoproteins. Members of this family have been recognized for their significant role in regulating early embryonic development, late tissue maturation in addition to spatially and temporally restricting target gene expression networks. When overexpressed, or rearranged into 'ETS' domain-containing chimeras, some of these proteins have been found to produce tumors. ESX (epithelial-restricted with serine box; ESE-1; ELF3; ERT; jen) is epithelial cell-specific and has been shown to regulate the expression of the HER2/neu (c-erbB2) oncogene in human breast cancer.

PA1-320 has been successfully used in Western blot protocols. By Western blot this antibody detects human ESX in T47D cell extract and in overexpressed transfected human cells using the ESX vector.

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