Q&A

Plasmid DNA Production for Cell and Gene Therapy

bacterial colonies for pDNA cloning iStock-180342961

High-quality plasmid DNA is a key component in cell and gene therapy manufacturing and as such is in high demand. This has led to the need to optimize manufacturing to meet the demand for volume as well as the quality required for use in the manufacture of therapeutics. Plasmid DNA (pDNA) manufacturing faces several challenges due to its large size, shear sensitivity, high viscosity, and the similarities between the pDNA and the impurities present during manufacturing. Thus, understanding all areas of the process are critical to successful manufacturing at a large scale.

With the high demand and quality requirements, it is important to seek out experts in the field who can illuminate the critical optimization opportunities for pDNA and answer questions about the production. We assembled a team of experts to answer questions on plasmid DNA production for cell and gene therapy applications.

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