Article | January 20, 2017

Overcoming Purification Hurdles With Mixed Mode Chromatography

biocompare logo

By Deborah Grainger & Peter A. Fung
First published September 12th, 2016 on www.Biocompare.com

Bacteria and viruses are nature’s shapeshifters, able to alter the make-up of their surface proteins in order to evade recognition by host immune systems. This strategy increases the virulence of these infectious agents and enables them to re-infect hosts, despite any previous encounters with the same pathogen. For example, the Neisseria genus of bacteria can vary the composition of their pili — protein polymers on their surface that play critical roles in bacterial adhesion [1]; whereas Streptococci bacteria often vary their expression of M-protein [2], an anti-phagocytic virulence factor that also blocks an immune process called opsonization. Such bacterial surface proteins are prime targets for vaccine development, and being able to capture and study them is a vital element of this work.

VIEW THE ARTICLE!
Signing up provides unlimited access to:
Signing up provides unlimited access to:
  • Trend and Leadership Articles
  • Case Studies
  • Extensive Product Database
  • Premium Content
HELLO. PLEASE LOG IN. X

Not yet a member of BioProcess Online? Register today.

ACCOUNT SIGN UP X
Please fill in your account details
Login Information
I'm interested in newsletter subscriptions.
ACCOUNT SIGN UP

Subscriptions

Sign up for the newsletter that brings you the industry's latest news, technologies, trends and products.

You might also want to: