White Paper

Optimizing Aliquoting For Robust Cell And Gene Therapy Processes

Source: Sartorius

By Maria Rende, Prisca Baptista, and Katy McLaughlin

Flexsafe® Bags

Aliquoting is a common practice in bioprocessing operations, where media and buffers are regularly formulated in large quantities and then divided into smaller containers for easier transport within the facility and handling at the point of use. Although aliquoting may seem like a simple operation conceptually, it greatly affects process efficiency and robustness, making it a crucial consideration in continuous process improvement.

Optimizing aliquoting is particularly critical in advanced therapies which are commonly high-value, low-volume applications that necessitate careful handling at small quantities. Unlike traditional biotherapeutics, advanced therapies do not benefit from standardized platform approaches. This is due to the inherent variability and novelty of the field, with regulatory standards and techniques still evolving.

This white paper explores the liquid handling challenges in cell and gene therapy processes and presents innovative solutions to simplify aliquoting in modern bioprocesses.

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