Application Note

Optimized Sterile Filtration of Pharmaceutical Solutions

Source: Parker Bioscience
bio filtration and separation

The cost of filtration and separation stages within the production of pharmaceuticals has been increasing along with the increased complexity of final drug products. The PROPOR HC, developed in partnership with a major pharmaceutical manufacturer, has been shown to overcome significant processing problems associated with their production of a drug intermediate. The previous costly requirement to reprocess batches due to difficulties in filtration has effectively been eliminated. The increase in throughput performance of the PROPOR HC compared to competitive products, is the result of newly developed PES membrane technology. This technology has also been shown to provide significant benefits with other protein based solutions such as serum free CHO-K1 medium and a 0.5 mg / ml protein concentration of dust mite serum.