Oncolytic Viruses Development And cGMP Manufacturing − Experience Matters

Oncolytic viruses (OVs) are natural or recombinant attenuated versions of common viruses that do not cause disease but instead infect tumor cells preferentially over healthy cells. The virus eventually kills infected cells, which releases molecular and cell-derived fragments that stimulate an immune response against the remaining cancerous tissue. This overall combined effect can occur with no prior knowledge of the cancer, its response to conventional treatments, or its specific antigenic composition.

OVs utilize a variety of viruses and vectors under current research and clinical trial – although limited commercial approvals exist to date. In this article, understand more about the leading OVs, the leading cell lines, and how to strategize your oncolytic virus production plan.