Novasep Introduces New BioSC Sequential Multi-Column Chromatography Product
Novasep Process, a global leader in advanced separation technologies for downstream processing of biologics has introduced the firm's Biopharmaceutical Sequential Chromatography (BioSC) product. The BioSC sequential multi-column chromatography product improves throughput and stationary phase productivity for downstream processes up to four-times without compromising product quality or yield. BioSC is the first product to break the "downstream processing bottleneck" by enabling biopharmaceutical firms to significantly improve the productivity (grams protein/liter, resin/day) of their current chromatography processes while simultaneously increasing process flow rates and dramatically decreasing water usage when compared to conventional batch column chromatography. BioSC simplifies existing processes by reducing the number and size of current process steps by more efficiently using the working capacity of the stationary phase and full automation of the continuous process. BioSC can accommodate the higher titers produced by modern upstream cell cultures while delivering continuous processes that maximize production efficiency and minimize product delays.
"BioSC provides an easy-to-implement, reliable solution to dramatically reduce the cost of downstream processing by 60%," said Stephen Tingley, Vice President Sales and Marketing, Novasep Process Biopharma. "BioSC lowers costs by reducing the production volumes of expensive stationary phase media, buffer solutions, water, capital equipment, specialized personnel and related manufacturing infrastructure," Tingley added.
"Initial modeling studies of a commercially relevant monoclonal antibody process clearly indicated the potential of a BioSC-based continuous downstream purification process to reduce the overall capital by up to 30%, equating to a cost of goods reduction of about 49%, with water usage reduced by up to 78% and overall downstream processing cost of goods up to 69%," said Andrew Sinclair, Managing Director, BioPharm Services.
About Novasep's BioSC Technology
BioSC enables the Biopharmaceutical industry to significantly increase productivity and improve manufacturing efficiency. By better using the capacity of expensive stationary phase resin during purification steps, biopharmaceutical firms can now produce more grams of Biopharmaceutical per litre of resin and reduce significantly water consumption (buffers, wash & CIP). This has significant impact on both facility size, cost of goods and ultimately on our environment by reducing waste. BioSC leverages a sequential multi-column chromatography process that provides flexible scheduling of multi-columns and high quality separations in critical multi-component feed streams. BioSC manages the "fluid in" and "fluid out" process while asynchronously and flexibly scheduling multiple columns to different tasks, the resins spend more time working and less time waiting. Each column is capable of working in different phases (loading, washing, eluting), and the more rapid wash and elute cycles are no longer influenced by the slower loading phase. As a result, flow into and out of the system does not have to be balanced. This enables the system to execute purification in a much more coordinated, faster and streamlined manner with higher loading capabilities and much less water consumption.
About Novasep Process
Novasep Process is the global leader in developing, scaling-up and the implementation of continuous downstream processing solutions for the Pharma, Biopharma and Industrial Biotech applications. Novasep Process Biopharma's proven purification solutions provide easy to implement, regulatory approved processes that enable significant cost benefits while exceeding quality requirements for existing and new drugs.
About Groupe Novasep
Groupe Novasep, with its headquarters near Nancy (in Eastern France), is a leading partner for the pharmaceutical, food, cosmetics, agrochemicals, and specialty chemicals industries through its two business segments – Novasep Process and Novasep Synthesis. Both strategic businesses are complementary organizations with skills designed to provide technically optimized and economical solutions for the life-science sector and related industries.
SOURCE: Novasep Process