Newsletter | March 3, 2025

03.03.25 -- New Reference Standards To Support Quality Of AAV Raw And Starting Materials

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As regulatory requirements tighten and ADCs become more complex, the 4th ADC Analytical Development Summit will help you navigate these challenges. Through expert-led discussions and case studies, gain practical solutions to key analytical issues like DAR quantification, aggregation measurement, and impurity analysis. Don’t miss this opportunity to enhance your expertise and ensure successful ADC development and regulatory submissions. Learn more here.

FOCUS ON UPSTREAM MANUFACTURING

New Reference Standards To Support Quality Of AAV Raw And Starting Materials

The United States Pharmacopeia aims to help gene therapy manufacturers address the challenges that come with complex starting materials like endonuclease and plasmids.

The Advantages Of A Blended Learning Approach In Operator Training

Explore blended learning and its advantages over traditional operator training methods, which often reduce training to a repetitive but necessary checklist of reading and acknowledging procedures.

The Power Of The Pool: Using Bulk Cultures For Clinical Trial Manufacturing

Stable bulk cultures, made highly uniform using transposase-mediated technologies, may be the key to expediting clone selection for many biopharmaceutical applications.

Study Viral Infection In Resting Humans CD4+ T Cells With Synthetic sgRNAs

Discover how Synthego's proprietary synthetic sgRNA, combined with Lonza’s 4D-Nucleofector®, enabled highly efficient gene editing in resting human CD4+ T cells.

Use Of 60 Micron Plastic (PE) Retention Filter For Perfusion Media Exchange

Explore guidance on the materials and methods recommended for assembling a perfusion system using a 60 Micron Plastic (PE) Retention Filter with a Vertical-Wheel Bioreactor.

The Role Of Cell Culture Media Growth Factors

Growth factors in cell culture media are essential for cell survival and behavior. Uncover their diverse roles and the science behind choosing the right ones.

Leveraging Novel Analytical Approaches For Advanced Therapies

Review the advantages and limitations of transcriptional assays versus reporter gene assays and how the transcriptional assay compares to ddPCR and flow cytometry for analysis of CGTs.

UPSTREAM MANUFACTURING SOLUTIONS

Techfors-S Pilot Bioreactor - INFORS HT

Monitor And Control Both Glucose And Lactate In Real-Time - 908 Devices

Plant 5 — Dream Plant: Within Your Reach. Built For Your Success. - Samsung Biologics

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