New Non-ionic Monomer Helps Chemists Achieve Novel Amine Polymer Architectures

Warrington, PA - Polysciences, Inc. introduces the N-(N-BOC-aminopropyl) methacrylamide monomer, the first commercially available, solvent-soluble blocked primary amine monomer. The new monomer makes it easier for chemists, biochemists, and materials scientists to access amine polymers - especially those containing primary amine groups.

Amines are among the most versatile synthetic handles and can act as bases, acids, nucleophiles, ligands for metals, and electron transfer agents. Polysciences' N-(N-BOC-aminopropyl) methacrylamide is a stable, easily-handled, white solid that is soluble in a range of organic solvents and copolymerizes readily with other vinylic monomers. This blocked monomer overcomes the interference that active amine hydrogens can have on radical polymerization techniques. The t-BOC group is easily deprotected to the free amine under mild conditions with a variety of reagents including HC1/MeOH and Me3SiI. As such, copolymers containing this monomer can be readily converted to primary amino copolymers, which can be further modified if desired by coupling to peptides, dyes, and more. The monomer itself can be converted into other reactive monomer analogs via the deprotection/coupling route and transformed into novel copolymer compositions and other amine polymer architectures.

N-(N-BOC-aminopropyl) methacrylamide compliments other Polysciences' amino functional monmers such as N(3-aminopropyl) methacrylamide hydrochloride. The product is the latest in Polysciences' complete line of custom and off-the-shelf specialty monomers and polymers.

SOURCE: Polysciences, Inc.