Newsletter | October 13, 2026

10.13.26 -- New Advances In Drug Safety With Human-Relevant Preclinical Models

New Approach Methodologies: The Future Of Toxicology And Safety Testing

NAMs are transforming toxicology with human-relevant, non-animal approaches. Learn what defines a NAM, how these methods work together, and why adoption is rapidly accelerating.

 

Ocaliva, Azelaprag, And The Challenge Of Drug-Induced Liver Injury

Recent liver safety concerns highlight the limits of conventional preclinical testing. Human-relevant models could help researchers detect drug-induced liver injury earlier and reduce costly setbacks.

 

The Application Of The Species-Specific Liver-Chip In Predicting Hepatoxicity

An evaluation of 150 drug candidates causing adverse events in humans revealed testing in rats and dogs predicted only 71% of toxicities in humans. Discover a solution to this translational challenge.

 

Advancing Safety And Improving R&D Productivity With The Liver-Chip S1

Gain insight into how the Emulate Liver-Chip S1 revolutionizes predictive toxicology by mimicking human liver biology, achieving superior sensitivity and specificity.

 

ON DEMAND WEBINAR

Advancing The Human Liver-Chip Toward FDA Qualification

Explore how human-relevant liver models can improve DILI risk assessment and support stronger development decisions while advancing toward regulatory qualification and scaling into automated studies.

 

IN THE NEWS

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Emulate Enters Final Stage Of FDA ISTAND Program For Human Liver-Chip With Submission Of Qualification Package Covering Both Zoë® And AVA™ Organ-Chip Platforms

EMULATE PRODUCT BROCHURE

Complete Organ-Chip Solutions To Fast-Track Your Drug Discovery

As regulatory momentum continues growing to reduce the use of animal models and adopt more human-relevant approaches, Emulate’s Organ-on-a-Chip technology can help researchers generate translational insights earlier in the R&D process and expedite their IND submissions. From toxicology and safety testing to biologics development, neuroscience, cancer biology, and personalized medicine, Emulate’s Organ-Chip platforms support more predictive and human-centric approaches to drug development and disease modeling.