Natrix® Q Chromatography Membrane Best Practices Guide

With an innovative macroporous hydrogel structure that provides a high density of binding sites and rapid mass transfer, Natrix® Q anion exchange (AEX) chromatography membranes deliver higher binding capacities than resin-based columns at fast flow rates typical of traditional membrane adsorbers. Exceptional impurity reduction is maintained over a wide range of operating conditions for improved process design flexibility and robustness. Natrix® Q products are easily scalable from laboratory to clinical and commercial manufacturing scale and are designed to work with existing chromatography systems. Featuring a disposable, plug-and-play device format, Natrix® Q enables highly productive and flexible solutions for purification of biologics.

In this guide we review the device installation and setup, process development, and implementation and scale up strategies.