mTOR Pathway

The mammalian target of rapamycin (mTOR) is a crucial regulator that orchestrates a broad spectrum of cellular activities. These activities include cell growth, metabolism, proliferation, motility, survival, transcription, and protein synthesis. The mTORC1 complex is particularly sensitive to rapamycin and comprises several key components: mTOR itself, the regulatory-associated protein of mTOR (Raptor), and the mammalian LST8 homolog (mLST8). Through these components, mTORC1 plays a pivotal role in mediating cell growth by regulating various processes such as translation, transcription, ribosome biogenesis, nutrient transport, and autophagy.

Discover how this intricate mTOR signaling pathway highlights how the serine/threonine-protein kinase mTOR governs a multitude of cellular processes, which ensures proper cellular function and adaptation to environmental cues.